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http://hdl.handle.net/2445/44444| Title: | The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine |
| Author: | Whitaker, Hayley C. Kote-Jarai, Zsofia Ross-Adams, Helen Warren, Anne Y. Burge, Johanna George, Anne Bancroft, Elizabeth K. Jhavar, Sameer Leongamornlert, Daniel Tymrakiewicz, Malgorzata Saunders, Edward J. Page, Elizabeth Mitra, Anita Mitchell, Gillian Lindeman, Geoffrey J. Evans, D. Gareth Blanco Guillermo, Ignacio Mercer, Catherine Rubinstein, Wendy S. Neal, David E. |
| Keywords: | Càncer de pròstata Oncogens Marcadors genètics Prostate cancer Oncogenes Genetic markers |
| Issue Date: | 13-Oct-2010 |
| Publisher: | Public Library of Science (PLoS) |
| Abstract: | Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk. |
| Note: | Reproducció del document publicat a: 10.1371/journal.pone.0013363 |
| It is part of: | PLoS One, 2010, vol. 5, num. 10, p. e13363 |
| URI: | http://hdl.handle.net/2445/44444 |
| Related resource: | http://dx.doi.org/10.1371/journal.pone.0013363 |
| ISSN: | 1932-6203 |
| Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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