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Title: The rs10993994 risk allele for prostate cancer results in clinically relevant changes in microseminoprotein-beta expression in tissue and urine
Author: Whitaker, Hayley C.
Kote-Jarai, Zsofia
Ross-Adams, Helen
Warren, Anne Y.
Burge, Johanna
George, Anne
Bancroft, Elizabeth
Jhavar, Sameer
Leongamornlert, Daniel
Tymrakiewicz, Malgorzata
Saunders, Edward
Page, Elizabeth
Mitra, Anita
Mitchell, Gillian
Lindeman, Geoffrey J.
Evans, D. Gareth
Blanco Guillermo, Ignacio
Mercer, Catherine
Rubinstein, Wendy S.
Neal, David E.
Keywords: Càncer de pròstata
Marcadors genètics
Prostate cancer
Genetic markers
Issue Date: 13-Oct-2010
Publisher: Public Library of Science (PLoS)
Abstract: Microseminoprotein-beta (MSMB) regulates apoptosis and using genome-wide association studies the rs10993994 single nucleotide polymorphism in the MSMB promoter has been linked to an increased risk of developing prostate cancer. The promoter location of the risk allele, and its ability to reduce promoter activity, suggested that the rs10993994 risk allele could result in lowered MSMB in benign tissue leading to increased prostate cancer risk.
Note: Reproducció del document publicat a: 10.1371/journal.pone.0013363
It is part of: PLoS One, 2010, vol. 5, num. 10, p. e13363
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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