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DC Field | Value | Language |
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dc.contributor.author | Campayo Guillaumes, Marc | - |
dc.contributor.author | Navarro Ponz, Alfons | - |
dc.contributor.author | Viñolas Segarra, Núria | - |
dc.contributor.author | Tejero Villalba, Rut | - |
dc.contributor.author | Muñoz García, Carmen | - |
dc.contributor.author | Díaz Sánchez, Tania | - |
dc.contributor.author | Marrades Sicart, Ramon Ma. | - |
dc.contributor.author | Cabanas, Maria L. | - |
dc.contributor.author | Gimferrer Garolera, José Ma. | - |
dc.contributor.author | Gascón, Pere | - |
dc.contributor.author | Ramírez Ruz, J. (José) | - |
dc.contributor.author | Monzó Planella, Mariano | - |
dc.date.accessioned | 2013-06-26T18:25:35Z | - |
dc.date.available | 2013-06-26T18:25:35Z | - |
dc.date.issued | 2011-07-25 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/44445 | - |
dc.description.abstract | MicroRNAs (miRNAs) play an important role in carcinogenesis through the regulation of their target genes. miRNA-related single nucleotide polymorphisms (miR-SNPs) can affect miRNA biogenesis and target sites and can alter microRNA expression and functions. We examined 11 miR-SNPs, including 5 in microRNA genes, 3 in microRNA binding sites and 3 in microRNA-processing machinery components, and evaluated time to recurrence (TTR) according to miR-SNP genotypes in 175 surgically resected non-small-cell lung cancer (NSCLC) patients. Significant differences in TTR were found according to KRT81 rs3660 (median TTR: 20.3 months for the CC genotype versus 86.8 months for the CG or GG genotype; P = 0.003) and XPO5 rs11077 (median TTR: 24.7 months for the AA genotype versus 73.1 months for the AC or CC genotypes; P = 0.029). Moreover, when patients were divided according to stage, these differences were maintained for stage I patients (P = 0.002 for KRT81 rs3660; P<0.001 for XPO5 rs11077). When patients were divided into sub-groups according to histology, the effect of the KRT81 rs3660 genotype on TTR was significant in patients with squamous cell carcinoma (P = 0.004) but not in those with adenocarcinoma. In the multivariate analyses, the KRT81 rs3660 CC genotype (OR = 1.8; P = 0.023) and the XPO5 rs11077 AA genotype (OR = 1.77; P = 0.026) emerged as independent variables influencing TTR. Immunohistochemical analyses in 80 lung specimens showed that 95% of squamous cell carcinomas were positive for KRT81, compared to only 19% of adenocarcinomas (P<0.0001). In conclusion, miR-SNPs are a novel class of SNPs that can add useful prognostic information on the clinical outcome of resected NSCLC patients and may be a potential key tool for selecting high-risk stage I patients. Moreover, KRT81 has emerged as a promising immunohistochemical marker for the identification of squamous cell lung carcinoma. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: 10.1371/journal.pone.0022509 | - |
dc.relation.ispartof | PLoS One, 2011, vol. 6, num. 7, p. e0022509 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0022509 | - |
dc.rights | cc-by (c) Campayo Guillaumes, Marc et al., 2011 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Micro RNAs | - |
dc.subject.classification | Carcinogènesi | - |
dc.subject.other | MicroRNAs | - |
dc.subject.other | Carcinogenesis | - |
dc.title | A dual role for KRT81: a miR-SNP associated with recurrence in non-small-cell lung cancer and a novel marker of squamous cell lung carcinoma | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 597285 | - |
dc.date.updated | 2013-06-26T18:25:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 21799879 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
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597285.pdf | 2.87 MB | Adobe PDF | View/Open |
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