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Title: Maslinic acid-enriched diet decreases intestinal tumorigenesis in ApcMin/+ mice through transcriptomic and metabolomic reprogramming
Author: Sánchez Tena, Susana
Reyes-Zurita, Fernando J.
Diaz Moralli, Santiago
Vinardell Martínez-Hidalgo, Ma. Pilar
Reed, Michelle
García-García, Francisco
Dopazo, Joaquín
Lupiáñez, José A.
Günther, Ulrich
Cascante i Serratosa, Marta
Keywords: Tumors
Càncer colorectal
Medicaments antineoplàstics
Colorectal cancer
Antineoplastic agents
Issue Date: 18-Mar-2013
Publisher: Public Library of Science (PLoS)
Abstract: Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancerrelated death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in ApcMin/+ mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P,0.01). Putative molecular mechanisms associated with suppressing intestinal polyposis in ApcMin/+ mice were investigated by comparing microarray expression profiles of MA-treated and control mice and by analyzing the serum metabolic profile using NMR techniques. The different expression phenotype induced by MA suggested that it exerts its chemopreventive action mainly by inhibiting cell-survival signaling and inflammation. These changes eventually induce G1-phase cell cycle arrest and apoptosis. Moreover, the metabolic changes induced by MA treatment were associated with a protective profile against intestinal tumorigenesis. These results show the efficacy and underlying mechanisms of MA against intestinal tumor development in the ApcMin/+ mice model, suggesting its chemopreventive potential against colorectal cancer.
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It is part of: PLoS One, 2013, vol. 8, num. 3, p. e59392
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Bioquímica i Fisiologia)

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