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http://hdl.handle.net/2445/47024
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DC Field | Value | Language |
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dc.contributor.author | Vestbo, Jørgen | - |
dc.contributor.author | Edwards, Lisa D. | - |
dc.contributor.author | Scanlon, Paul D. | - |
dc.contributor.author | Yates, Julie C. | - |
dc.contributor.author | Agustí García-Navarro, Àlvar | - |
dc.contributor.author | Bakke, Per | - |
dc.contributor.author | Calverley, Peter M. | - |
dc.contributor.author | Celli, Bartolome R. | - |
dc.contributor.author | Coxson, Harvey O. | - |
dc.contributor.author | Crim, Courtney | - |
dc.contributor.author | Lomas, David A. | - |
dc.contributor.author | MacNee, William | - |
dc.contributor.author | Miller, Bruce E. | - |
dc.contributor.author | Silverman, Edwin K. | - |
dc.contributor.author | Tal-Singer, Ruth | - |
dc.contributor.author | Wouters, Emiel | - |
dc.contributor.author | Rennard, Stephen I. | - |
dc.date.accessioned | 2013-10-16T09:30:15Z | - |
dc.date.available | 2013-10-16T09:30:15Z | - |
dc.date.issued | 2011-09-26 | - |
dc.identifier.issn | 0028-4793 | - |
dc.identifier.uri | http://hdl.handle.net/2445/47024 | - |
dc.description.abstract | Background A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated rate of decline in forced expiratory volume in 1 second (FEV 1), but data on the variability and determinants of this change in patients who have established disease are scarce. Methods We analyzed the changes in FEV 1 after administration of a bronchodilator over a 3-year period in 2163 patients. A random-coefficient model was used to evaluate possible predictors of both FEV 1 levels and their changes over time. Results The mean (±SE) rate of change in FEV 1 was a decline of 33±2 ml per year, with sig - nificant variation among the patients studied. The between-patient standard deviation for the rate of decline was 59 ml per year. Over the 3-year study period, 38% of patients had an estimated decline in FEV 1 of more than 40 ml per year, 31% had a decline of 21 to 40 ml per year, 23% had a change in FEV 1 that ranged from a de - crease of 20 ml per year to an increase of 20 ml per year, and 8% had an increase of more than 20 ml per year. The mean rate of decline in FEV 1 was 21±4 ml per year greater in current smokers than in current nonsmokers, 13±4 ml per year greater in patients with emphysema than in those without emphysema, and 17±4 ml per year greater in patients with bronchodilator reversibility than in those without reversibility. Conclusions The rate of change in FEV 1 among patients with COPD is highly variable, with increased rates of decline among current smokers, patients with bronchodilator reversibility, and patients with emphysema. (Funded by GlaxoSmithKline; ECLIPSE ClinicalTrials.gov number, NCT00292552). | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Massachusetts Medical Society | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1056/NEJMoa1105482 | - |
dc.relation.ispartof | New England Journal of Medicine, 2011, vol. 365, num. 13, p. 1184-1192 | - |
dc.relation.uri | http://dx.doi.org/10.1056/NEJMoa1105482 | - |
dc.rights | (c) Massachusetts Medical Society, 2011 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.classification | Assaigs clínics de medicaments | - |
dc.subject.classification | Broncodilatadors | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.subject.other | Drug testing | - |
dc.subject.other | Bronchodilator agents | - |
dc.title | Changes in forced expiratory volume in 1 second over time in COPD | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 609813 | - |
dc.date.updated | 2013-10-16T09:30:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 21991892 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
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609813.pdf | 565.74 kB | Adobe PDF | View/Open |
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