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Title: Snail blocks the cell cycle and confers resistance to cell death
Author: Vega, Sonia
Morales, Aixa V.
Ocaña, Oscar H.
Valdés, Francisco
Fabregat Romero, Isabel
Nieto, M. Angela
Keywords: Mort cel·lular
Trastorns del desenvolupament
Cell death
Developmental disabilities
Human beings
Issue Date: 15-May-2004
Publisher: Cold Spring Harbor Laboratory Press
Abstract: The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in cell shape and the expression of mesenchymal markers. Here, we show that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals. Hence, Snail favors changes in cell shape versus cell division, indicating that with respect to oncogenesis, although a deregulation/increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization. Finally, the resistance to cell death conferred by Snail provides a selective advantage to embryonic cells to migrate and colonize distant territories, and to malignant cells to separate from the primary tumor, invade, and form metastasis.
Note: Reproducció del document publicat a:
It is part of: Genes & Development, 2004, vol. 18, p. 1131-1143
Related resource:
ISSN: 0890-9369
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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