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Title: Emerging functions of myelin associated proteins during development neuronal plasticity and and neurpdegeneration.
Author: Llorens, Franc
Gil, V.
Río Fernández, José Antonio del
Keywords: Sistema nerviós central
Regeneració del sistema nerviós
Expressió gènica
Proteïnes de membrana
Hipocamp (Cervell)
Central nervous system
Nervous system regeneration
Gene expression
Membrane proteins
Myelin sheath
Hippocampus (Brain)
Issue Date: Feb-2011
Publisher: The Federation of American Society of Experimental Biology
Abstract: Adult mammalian central nervous system (CNS) axons have a limited regrowth capacity following injury. Myelin-associated inhibitors (MAIs) limit axonal outgrowth and their blockage improves the regeneration of damaged fiber tracts. Three of these proteins, Nogo-A, MAG and OMgp, share two common neuronal receptors: NgR1, together with its co-receptors (p75(NTR), TROY and Lingo-1), and the recently described paired immunoglobulin-like receptor B (PirB). These proteins impair neuronal regeneration by limiting axonal sprouting. Some of the elements involved in the myelin inhibitory pathways may still be unknown, but the discovery that blocking both PirB and NgR1 activities leads to near-complete release from myelin inhibition, sheds light on one of the most competitive and intense fields of neuroregeneration study during in recent decades. In parallel with the identification and characterization of the roles and functions of these inhibitory molecules in axonal regeneration, data gathered in the field strongly suggest that most of these proteins have roles other than axonal growth inhibition. The discovery of a new group of interacting partners for myelin-associated receptors and ligands, as well as functional studies within or outside the CNS environment, highlights the potential new physiological roles for these proteins in processes such as development, neuronal homeostasis, plasticity and neurodegeneration.
Note: Reproducció del document publicat a:
It is part of: The FASEB Journal , 2011, vol. 25, num. 2, p. 463-475
Related resource:
ISSN: 0892-6638
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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