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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/48344
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dc.contributor.authorVelasco Turbau, Javier-
dc.contributor.authorAriza Piquer, Xavier-
dc.contributor.authorBadía, Laura-
dc.contributor.authorBartra Sanmartí, Martí-
dc.contributor.authorBerenguer, Ramon-
dc.contributor.authorFarràs i Soler, Jaume-
dc.contributor.authorGallardo, Joan-
dc.contributor.authorGarcía Gómez, Jordi-
dc.contributor.authorGasanz, Yolanda-
dc.date.accessioned2013-12-09T08:47:09Z-
dc.date.available2014-12-31T23:02:05Z-
dc.date.issued2013-
dc.identifier.issn0022-3263-
dc.identifier.urihttp://hdl.handle.net/2445/48344-
dc.description.abstractEntecavir (BMS-200475) was synthesized from 4-trimethylsilyl-3-butyn-2-one and acrolein. The key features of its preparation are: (i) a stereoselective boron-aldol reaction to afford the acyclic carbon skeleton of the methylenecylopentane moiety; (ii) its cyclization by a Cp2TiCl-catalyzed intramolecular radical addition of an epoxide to an alkyne; and (iii) the coupling with a purine derivative by a Mitsunobu reaction.-
dc.format.extent35 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherAmerican Chemical Society-
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1021/jo400607v-
dc.relation.ispartofJournal of Organic Chemistry, 2013, vol. 78, num. 11, p. 5482-5491-
dc.relation.urihttp://dx.doi.org/10.1021/jo400607v-
dc.rights(c) American Chemical Society , 2013-
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)-
dc.subject.classificationHepatitis B-
dc.subject.classificationMedicaments antivírics-
dc.subject.classificationReacció aldòlica-
dc.subject.classificationÀcids nucleics-
dc.subject.otherHepatitis B-
dc.subject.otherAntiviral agents-
dc.subject.otherAldol reaction-
dc.subject.otherNucleic acids-
dc.titleTotal synthesis of entecavireng
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec626257-
dc.date.updated2013-12-05T13:06:51Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid23678976-
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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