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Title: On the role of G protein-coupled receptors oligomerization
Author: Gómer Soler, Maricel
Ahern, Siobhán
Fernández Dueñas, Víctor
Ciruela Alférez, Francisco
Keywords: Proteïnes G
Receptors cel·lulars
G Proteins
Cell receptors
Issue Date: 26-May-2011
Publisher: Bentham Open
Abstract: The existence of a supramolecular organization of the G protein-coupled receptor (GPCR) is now being widely accepted by the scientific community. Indeed, GPCR oligomers may enhance the diversity and performance by which extracellular signals are transferred to the G proteins in the process of receptor transduction, although the mechanism that underlies this phenomenon still remains unsolved. Recently, it has been proposed that a trans-conformational switching model could be the mechanism allowing direct inhibition/activation of receptor activation/inhibition, respectively. Thus, heterotropic receptor-receptor allosteric regulations are behind the GPCR oligomeric function. In this paper we want to revise how GPCR oligomerization impinges on several important receptor functions like biosynthesis, plasma membrane diffusion or velocity, pharmacology and signaling. In particular, the rationale of receptor oligomerization might lie in the need of sensing complex whole cell extracellular signals and translating them into a simple computational model.
Note: Reproducció del document publicat a:
It is part of: The Open Biology Journal, 2011, vol. 4, num. 1, p. 47-53
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ISSN: 1874-1967
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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