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http://hdl.handle.net/2445/48634| Title: | Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions |
| Author: | Isidro Llobet, Albert Just Baringo, Xavier Ewenson, Ariel Álvarez Domingo, Mercedes Albericio Palomera, Fernando |
| Keywords: | Reaccions químiques Síntesi de pèptids Chemical reactions Peptide synthesis |
| Issue Date: | 2007 |
| Publisher: | Wiley |
| Abstract: | A double side-reaction, consisting in the formation of Fmoc--Ala-OH and Fmoc--Ala-AA-OH, during the preparation of Fmoc protected amino acids (Fmoc-AA-OH) with Fmoc-OSu is discussed. Furthermore, the new Fmoc-2-MBT reagent is proposed for avoiding these side-reactions as well as the formation of the Fmoc-dipeptides (Fmoc-AA-AA-OH) and even tripeptides, which is another important side-reaction when chloroformates such as Fmoc-Cl is used for the protection of the -amino function of the amino acids. |
| It is part of: | Biopolymers, 2007, vol. 88, num. 5, p. 733-737 |
| URI: | http://hdl.handle.net/2445/48634 |
| ISSN: | 0006-3525 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 549100.pdf | 126.23 kB | Adobe PDF | View/Open |
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