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Title: Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions
Author: Isidro Llobet, Albert
Just Baringo, Xavier
Ewenson, Ariel
Álvarez Domingo, Mercedes
Albericio Palomera, Fernando
Keywords: Reaccions químiques
Síntesi de pèptids
Chemical reactions
Peptide synthesis
Issue Date: 2007
Publisher: Wiley
Abstract: A double side-reaction, consisting in the formation of Fmoc--Ala-OH and Fmoc--Ala-AA-OH, during the preparation of Fmoc protected amino acids (Fmoc-AA-OH) with Fmoc-OSu is discussed. Furthermore, the new Fmoc-2-MBT reagent is proposed for avoiding these side-reactions as well as the formation of the Fmoc-dipeptides (Fmoc-AA-AA-OH) and even tripeptides, which is another important side-reaction when chloroformates such as Fmoc-Cl is used for the protection of the -amino function of the amino acids.
It is part of: Biopolymers, 2007, vol. 88, num. 5, p. 733-737
ISSN: 0006-3525
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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