Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió acceptadaData de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/48635
Convergent Approaches for the Synthesis of the Anti-tumoral Peptide, Kahalalide F. Study of Orthogonal Protecting Groups
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Resum
Kahalalide compounds are peptides that are isolated from a Hawaiian herbivorous marine species of mollusc, Elysia rufescens, and its diet, the green alga Bryopsis sp. Kahalalide F and its synthetic analogues are the most promising compounds of the Kahalalide family because they show anti-tumoral activity. Linear solid-phase syntheses of Kahalalide F have been reported. Here we describe several new improved synthetic routes based on convergent approaches with distinct orthogonal protection schemes for the preparation of Kahaladide analogues. These strategies allow a better control and characterization of the intermediates because more reactions are performed in solution. Five derivatives of Kahalalide F were synthesized using several convergent approaches.
Descripció
Matèries (anglès)
Citació
Citació
GRACIA, Carolina, ISIDRO LLOBET, Albert, CRUZ, Luis j., ACOSTA, Gerardo a., ÁLVAREZ DOMINGO, Mercedes, CUEVAS, Carmen, GIRALT LLEDÓ, Ernest, ALBERICIO PALOMERA, Fernando. Convergent Approaches for the Synthesis of the Anti-tumoral Peptide, Kahalalide F. Study of Orthogonal Protecting Groups. _Journal of Organic Chemistry_. 2006. Vol. 71, núm. 7196. [consulta: 5 de desembre de 2025]. ISSN: 0022-3263. [Disponible a: https://hdl.handle.net/2445/48635]