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|Title:||Convergent Approaches for the Synthesis of the Anti-tumoral Peptide, Kahalalide F. Study of Orthogonal Protecting Groups|
Isidro Llobet, Albert
Cruz, Luis J.
Acosta, Gerardo A.
Álvarez Domingo, Mercedes
Giralt Lledó, Ernest
Albericio Palomera, Fernando
Productes marins naturals
Marine natural products
|Publisher:||American Chemical Society|
|Abstract:||Kahalalide compounds are peptides that are isolated from a Hawaiian herbivorous marine species of mollusc, Elysia rufescens, and its diet, the green alga Bryopsis sp. Kahalalide F and its synthetic analogues are the most promising compounds of the Kahalalide family because they show anti-tumoral activity. Linear solid-phase syntheses of Kahalalide F have been reported. Here we describe several new improved synthetic routes based on convergent approaches with distinct orthogonal protection schemes for the preparation of Kahaladide analogues. These strategies allow a better control and characterization of the intermediates because more reactions are performed in solution. Five derivatives of Kahalalide F were synthesized using several convergent approaches.|
|It is part of:||Journal of Organic Chemistry, 2006, vol. 71, p. 7196|
|Appears in Collections:||Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)|
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