Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/48645
Title: Oxidative Stress and Antioxidant Activity in Hypothermia and Rewarming. Can RONS Modulate the Beneficial Effects of Therapeutic Hypothermia?
Author: Alva Bocanegra, Norma V. (Norma Violeta)
Palomeque Rico, Jesús
Carbonell i Camós, Teresa
Keywords: Hipotèrmia
Anoxèmia
Estrès oxidatiu
Ús terapèutic
Hypothermia
Anoxemia
Oxidative stress
Therapeutic use
Issue Date: 21-Oct-2013
Publisher: Hindawi
Abstract: Hypothermia is a condition in which core temperature drops below the level necessary to maintain bodily functions. The decrease in temperature may disrupt some physiological systems of the body, including alterations in microcirculation and reduction of oxygen supply to tissues. The lack of oxygen can induce the generation of reactive oxygen and nitrogen free radicals (RONS), followed by oxidative stress, and finally, apoptosis and/or necrosis. Furthermore, since the hypothermia is inevitably followed by a rewarming process, we should also consider its effects. Despite hypothermia and rewarming inducing injury, many benefits of hypothermia have been demonstrated when used to preserve brain, cardiac, hepatic, and intestinal function against ischemic injury. This review gives an overview of the effects of hypothermia and rewarming on the oxidant/antioxidant balance and provides hypothesis for the role of reactive oxygen species in therapeutic hypothermia.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1155/2013/957054
It is part of: Oxidative Medicine and Cellular Longevity, 2013, vol. 2013
Related resource: http://dx.doi.org/10.1155/2013/957054
URI: http://hdl.handle.net/2445/48645
ISSN: 1942-0900
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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