Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/48647
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Isidro Llobet, Albert | - |
dc.contributor.author | Guasch Camell, Judit | - |
dc.contributor.author | Álvarez Domingo, Mercedes | - |
dc.contributor.author | Albericio Palomera, Fernando | - |
dc.date.accessioned | 2013-12-20T14:10:29Z | - |
dc.date.available | 2014-11-01T23:01:51Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1434-193X | - |
dc.identifier.uri | http://hdl.handle.net/2445/48647 | - |
dc.description.abstract | p-Nitrobenzyloxycarbonyl was used as temporary protecting group for the -amino function in solid-phase peptide synthesis. The corresponding derivatives are solids, easy to be synthesized, and perform well in the solid-phase mode. pNZ is removed in practical neutral conditions in the presence of catalytic amounts of acid. They are orthogonal with the most common protecting groups used in peptide chemistry. They are specially useful in combination with Fmoc chemistry to overcome those side reactions associated with the used of the piperidine such DKP and aspartiimide formation. The flexibility of pNZ can be very useful for the preparation of libraries of small organic molecules. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.ispartof | European Journal of Organic Chemistry, 2005, p. 3031-3039 | - |
dc.rights | (c) Wiley-VCH Verlag GmbH & Co. KGaA, 2005 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Química combinatòria | - |
dc.subject.other | Combinatorial chemistry | - |
dc.title | p-Nitrobenzyloxycarbonyl (pNZ) as Temporary Na-Protecting Group for Mild Solid-Phase Peptide Synthesis. Avoiding Diketopiperazine and Aspartimide Formation | eng |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/submittedVersion | - |
dc.identifier.idgrec | 521205 | - |
dc.date.updated | 2013-12-20T12:41:49Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
521205.pdf | 149.08 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.