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http://hdl.handle.net/2445/49087
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DC Field | Value | Language |
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dc.contributor.author | Fuxe, Kjell | - |
dc.contributor.author | Borroto Escuela, Dasiel Oscar | - |
dc.contributor.author | Romero Fernández, Wilber | - |
dc.contributor.author | Tarakanov, Alexander O. | - |
dc.contributor.author | Calvo, Feliciano | - |
dc.contributor.author | Garriga, Pere | - |
dc.contributor.author | Tena, Mercé | - |
dc.contributor.author | Narváez, Manuel | - |
dc.contributor.author | Millón, Carmelo | - |
dc.contributor.author | Parrado, Concepción | - |
dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.contributor.author | Agnati, Luigi F. | - |
dc.contributor.author | Narváez, José A. | - |
dc.contributor.author | Díaz Cabiale, Zaida | - |
dc.date.accessioned | 2014-01-22T10:05:24Z | - |
dc.date.available | 2014-01-22T10:05:24Z | - |
dc.date.issued | 2012-10-26 | - |
dc.identifier.issn | 1664-2392 | - |
dc.identifier.uri | http://hdl.handle.net/2445/49087 | - |
dc.description.abstract | Galanin receptor (GalR) subtypes 1-3 linked to central galanin neurons may form heteromers with each other and other types of G protein-coupled receptors in the central nervous system (CNS). These heteromers may be one molecular mechanism for galanin peptides and their N-terminal fragments (gal 1-15) to modulate the function of different types of glia-neuronal networks in the CNS, especially the emotional and the cardiovascular networks. GalR-5-HT1A heteromers likely exist with antagonistic GalR-5-HT1A receptor-receptor interactions in the ascending midbrain raphe 5-HT neuron systems and their target regions. They represent a novel target for antidepressant drugs. Evidence is given for the existence of GalR1-5-HT1A heteromers in cellular models with trans-inhibition of the protomer signaling. A GalR1-GalR2 heteromer is proposed to be a galanin N-terminal fragment preferring receptor (1-15) in the CNS. Furthermore, a GalR1-GalR2-5-HT1A heterotrimer is postulated to explain why only galanin (1-15) but not galanin (1-29) can antagonistically modulate the 5-HT1A receptors in the dorsal hippocampus rich in gal fragment binding sites. The results underline a putative role of different types of GalR-5-HT1A heteroreceptor complexes in depression. GalR antagonists may also have therapeutic actions in depression by blocking the antagonistic GalR-NPYY1 receptor interactions in putative GalR-NPYY1 receptor heteromers in the CNS resulting in increases in NPYY1 transmission and antidepressant effects. In contrast the galanin fragment receptor (a postulated GalR1-GalR2 heteromer) appears to be linked to the NPYY2 receptor enhancing the affinity of the NPYY2 binding sites in a putative GalR1-GalR2-NPYY2 heterotrimer. Finally, putative GalR-α2-adrenoreceptor heteromers with antagonistic receptor-receptor interactions may be a widespread mechanism in the CNS for integration of galanin and noradrenaline signals also of likely relevance for depression | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.3389/fendo.2012.00127 | - |
dc.relation.ispartof | Frontiers in Endocrinology, 2012, vol. 3, p. 1-12 | - |
dc.relation.uri | http://dx.doi.org/10.3389/fendo.2012.00127 | - |
dc.rights | cc-by (c) Fuxe, Kjell et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Receptors de serotonina | - |
dc.subject.classification | Sistema nerviós central | - |
dc.subject.classification | Proteïnes G | - |
dc.subject.other | Serotonin receptors | - |
dc.subject.other | Central nervous system | - |
dc.subject.other | G Proteins | - |
dc.title | On the existence and function of galanin receptor heteromers in the central nervous system | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 617235 | - |
dc.date.updated | 2014-01-22T10:05:24Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23112793 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
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