Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/49275
Title: Pneumococcal penumonia presenting with septic shock: host-ant pathogen-related factors and outcomes
Author: García Vidal, Carolina
Ardanuy Tisaire, María Carmen
Tubau, Fe
Viasus, Diego
Dorca i Sargatal, Jordi
Liñares Louzao, Josefina
Gudiol i Munté, Francesc
Carratalà, Jordi
Keywords: Pneumònia
Xoc sèptic
Mortalitat
Corticosteroides
Hàbit de fumar
Pneumonia
Septic shock
Mortality
Adrenocortical hormones
Tobbacco habit
Issue Date: 8-Dec-2009
Publisher: BMJ Publishing Group
Abstract: BACKGROUND: Host- and pathogen-related factors associated with septic shock in pneumococcal pneumonia are not well defined. The aim of this study was to identify risk factors for septic shock and to ascertain patient outcomes. Serotypes, genotypes and antibiotic resistance of isolated strains were also analysed. METHODS: Observational analysis of a prospective cohort of non-severely immunosuppressed hospitalised adults with pneumococcal pneumonia. Septic shock was defined as a systolic blood pressure of <90 mm Hg and peripheral hypoperfusion with the need for vasopressors for >4 h after fluid replacement. RESULTS: 1041 patients with pneumococcal pneumonia diagnosed by Gram stain and culture of appropriate samples and/or urine antigen test were documented, of whom 114 (10.9%) had septic shock at admission. After adjustment, independent risk factors for shock were current tobacco smoking (OR, 2.11; 95% CI, 1.02 to 4.34; p = 0.044), chronic corticosteroid treatment (OR, 4.45; 95% CI, 1.75 to 11.32; p = 0.002) and serotype 3 (OR, 2.24; 95% CI, 1.12 to 4.475; p = 0.022). No significant differences were found in genotypes and rates of antibiotic resistance. Compared with the remaining patients, patients with septic shock required mechanical ventilation more frequently (37% vs 4%; p<0.001) and had longer length of stay (11 vs 8 days; p<0.001). The early (10% vs 1%; p<0.001) and overall case fatality rates (25% vs 5%; p<0.001) were higher in patients with shock. CONCLUSIONS: Septic shock is a frequent complication of pneumococcal pneumonia and causes high morbidity and mortality. Current tobacco smoking, chronic corticosteroid treatment and infection caused by serotype 3 are independent risk factors for this complication.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1136/thx.2009.123612
It is part of: Thorax, 2009, vol. 65, num. 1, p. 77-81
Related resource: http://dx.doi.org/10.1136/thx.2009.123612
URI: http://hdl.handle.net/2445/49275
ISSN: 0040-6376
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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