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Title: Metabolomic assays of amoxicillin, cephapirin and ceftiofur in chicken muscle. Application to treated chicken samples by liquid chromatography quadrupole time-of-flight mass spectrometry
Author: Hermo Outeiral, Ma. del Pilar
Gómez-Rodríguez, P.
Barbosa Torralbo, José
Barrón Bueno, Dolores
Keywords: Amoxicil·lina
Antibiòtics betalactàmics
Beta lactam antibiotics
Issue Date: 2013
Publisher: Elsevier B.V.
Abstract: The aim of this study was to identity metabolites and transformation products (TPs) in chicken muscle from amoxicillin (AMX), cephapirin (PIR) and ceftiofur (TIO), which are antibiotics of the β-lactam family. Liquid chromatography coupled to quadrupole time-of-flight (QqTOF) mass spectrometry was utilized due to its high resolution, high mass accuracy and MS/MS capacity for elemental composition determination and structural elucidation. Amoxicilloic acid (AMA) and amoxicillin diketopiperazine (DKP) were found as transformation products from AMX. Desacetylcephapirin (DAC) was detected as a metabolite of PIR. Desfuroylceftiofur (DFC) and its conjugated compound with cysteine (DFC-S-Cys) were detected as a result of TIO in contact with chicken muscle tissue. The metabolites and transformation products were also monitored during the in vivo AMX treatment and slaughtering period. It was found that two days were enough to eliminate AMX and associated metabolites/transformation products after the end of administration.
Note: Versió postprint del document publicat a:
It is part of: Journal of Pharmaceutical and Biomedical Analysis, 2013, vol. 85, p. 169-178
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ISSN: 0731-7085
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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