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Title: Constitutive expression of FGF4 disrupts the development of the eye and the anterior CNS during mouse embryogenesi, but does not influence the expressionof shh in these areas.
Author: Bueno i Torrens, David, 1965-
Abud, Helen
Skinner, Judith
Heath, John K.
Keywords: Genètica del desenvolupament
Sistema nerviós central
Ratolins (Animals de laboratori)
Factors de creixement
Developmental genetics
Central nervous system
Mice (Laboratory animals)
Growth factors
Issue Date: Jan-2001
Publisher: Royal Belgian Zoological Society
Abstract: The biological consequences of constitutive fibroblast growth factor-4 (fgf4) expression have been analysed during anterior CNS development of mouse chimeric embryos. Severe mutant embryos exhibit exencephaly, absence of eye development and anomalous differentiation of neuropithelium. These embryos also show ectopic limb buds resembling the early phases of limb development. Because our results show that anterior CNS in those chimeric embrios does not express shh ectopically, we suggest that malformations may be due to interference between the ectopic expression of fgf4 in the cephalic area and the receptors for the members of the FGF family that regulate brain and eye development, namely fgf8. If this is correct, the results indirectly suport the crucial role of fgf8 in patterning the anterior CNS.
Note: Reproducció del document publicat a:,%20pp.%2057-62.pdf
It is part of: Belgian Journal of Zoology, 2001, vol. 131, p. 57-62
ISSN: 0777-6276
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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