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http://hdl.handle.net/2445/49423
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DC Field | Value | Language |
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dc.contributor.author | Elduque Busquets, Xavier | - |
dc.contributor.author | Sánchez-Moya, Albert | - |
dc.contributor.author | Sharma, Kapil | - |
dc.contributor.author | Pedroso Muller, Enrique | - |
dc.contributor.author | Grandas Sagarra, Anna | - |
dc.date.accessioned | 2014-02-05T09:00:14Z | - |
dc.date.available | 2014-12-31T23:02:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | http://hdl.handle.net/2445/49423 | - |
dc.description.abstract | Monomers allowing for the introduction of [2,5-dimethylfuran]-protected maleimides into polyamides such as peptides, peptide nucleic acids, and peptoids were prepared, as well as the corresponding oligomers. Suitable maleimide deprotection conditions were established in each case. The stability of the adducts generated by Michael-type maleimide-thiol reaction and Diels-Alder cycloaddition to maleimide deprotection conditions was exploited to prepare a variety of conjugates from peptide and PNA scaffolds incorporating one free and one protected maleimide. The target molecules were synthesized by using two subsequent maleimide-involving click reactions separated by a maleimide deprotection step. Carrying out maleimide deprotection and conjugation simultaneously gave better results than performing the two reactions subsequently. | - |
dc.format.extent | 24 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1021/bc4000614 | - |
dc.relation.ispartof | Bioconjugate Chemistry, 2013, vol. 24, num. 5, p. 832-839 | - |
dc.relation.uri | http://dx.doi.org/10.1021/bc4000614 | - |
dc.rights | (c) American Chemical Society , 2013 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Pèptids | - |
dc.subject.classification | Àcids nucleics | - |
dc.subject.classification | Oligòmers | - |
dc.subject.classification | Síntesi orgànica | - |
dc.subject.classification | Biotecnologia | - |
dc.subject.classification | Aminoàcids | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | Peptides | - |
dc.subject.other | Nucleic acids | - |
dc.subject.other | Oligomers | - |
dc.subject.other | Organic synthesis | - |
dc.subject.other | Biotechnology | - |
dc.subject.other | Amino acids | - |
dc.subject.other | Proteins | - |
dc.title | Protected maleimide building blocks for the decoration of peptides, peptoids and peptide nucleic acids | eng |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 631976 | - |
dc.date.updated | 2014-02-04T15:10:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23582188 | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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631976.pdf | 1.86 MB | Adobe PDF | View/Open |
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