Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/49472
Title: | Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes |
Author: | Sánchez-Moya, Albert Pedroso Muller, Enrique Grandas Sagarra, Anna |
Keywords: | Biotecnologia Àcids nucleics Espectrometria de masses Nucleòtids Compostos heterocíclics Biotechnology Nucleic acids Mass spectrometry Nucleotides Heterocyclic compounds |
Issue Date: | 2012 |
Publisher: | Royal Society of Chemistry |
Abstract: | [2,5-Dimethylfuran]-protected maleimides were placed at both internal positions and the 3'-end of oligonucleotides making use of solid-phase synthesis procedures. A new phosphoramidite derivative and a new solid support incorporating the protected maleimide moiety were prepared for this purpose. In all cases maleimide deprotection (retro-Diels-Alder reaction) followed by reaction with thiol-containing compounds afforded the target conjugate. |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.1039/c2ob26514a |
It is part of: | Organic & Biomolecular Chemistry, 2012, vol. 10, num. 42, p. 8478-8483 |
URI: | http://hdl.handle.net/2445/49472 |
Related resource: | http://dx.doi.org/10.1039/c2ob26514a |
ISSN: | 1477-0520 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
616925.pdf | 1.1 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.