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Title: Easy introduction of maleimides at different positions of oligonucleotide chains for conjugation purposes
Author: Sánchez, Albert
Pedroso Muller, Enrique
Grandas Sagarra, Anna
Keywords: Biotecnologia
Àcids nucleics
Espectrometria de masses
Compostos heterocíclics
Nucleic acids
Mass spectrometry
Heterocyclic compounds
Issue Date: 2012
Publisher: Royal Society of Chemistry
Abstract: [2,5-Dimethylfuran]-protected maleimides were placed at both internal positions and the 3'-end of oligonucleotides making use of solid-phase synthesis procedures. A new phosphoramidite derivative and a new solid support incorporating the protected maleimide moiety were prepared for this purpose. In all cases maleimide deprotection (retro-Diels-Alder reaction) followed by reaction with thiol-containing compounds afforded the target conjugate.
Note: Versió postprint del document publicat a:
It is part of: Organic & Biomolecular Chemistry, 2012, vol. 10, num. 42, p. 8478-8483
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ISSN: 1477-0520
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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