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Title: Straightforward synthesis of cyclic and bicyclic peptides
Author: Elduque Busquets, Xavier
Pedroso Muller, Enrique
Grandas Sagarra, Anna
Keywords: Aminoàcids
Amino acids
Issue Date: 2013
Publisher: American Chemical Society
Abstract: Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the trifluoroacetic acid treatment, if the maleimide is not protected, or upon deprotection of the maleimide. The combination of free and protected maleimide moieties and two orthogonally protected cysteines gives access to structurally different bicyclic peptides with isolated or fused cycles.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2013, vol. 15, num. 8, p. 2038-2041
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ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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