Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/49479
Title: Straightforward synthesis of cyclic and bicyclic peptides
Author: Elduque Busquets, Xavier
Pedroso Muller, Enrique
Grandas Sagarra, Anna
Keywords: Aminoàcids
Pèptids
Proteïnes
Amino acids
Peptides
Proteins
Issue Date: 2013
Publisher: American Chemical Society
Abstract: Cyclic peptide architectures can be easily synthesized from cysteine-containing peptides with appending maleimides, free or protected, through an intramolecular Michael-type reaction. After peptide assembly, the peptide can cyclize either during the trifluoroacetic acid treatment, if the maleimide is not protected, or upon deprotection of the maleimide. The combination of free and protected maleimide moieties and two orthogonally protected cysteines gives access to structurally different bicyclic peptides with isolated or fused cycles.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1021/ol400726y
It is part of: Organic Letters, 2013, vol. 15, num. 8, p. 2038-2041
Related resource: http://dx.doi.org/10.1021/ol400726y
URI: http://hdl.handle.net/2445/49479
ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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