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Title: Depression-like behavior is dependent on age in male SAMP8 mice
Author: Pérez-Cáceres, D.
Ciudad Roberts, Andrés
Rodrigo i Calduch, Ma. Teresa
Pubill Sánchez, David
Camins Espuny, Antoni
Camarasa García, Jordi
Escubedo Rafa, Elena
Pallàs i Llibería, Mercè, 1964-
Keywords: Envelliment
Depressió psíquica
Ratolins (Animals de laboratori)
Mental depression
Animal behavior
Mice (Laboratory animals)
Issue Date: 5-Apr-2013
Publisher: Springer Science + Business Media
Abstract: Aging is associated with an increased risk of depression in humans. To elucidate the underlying mechanisms of depression and its dependence on aging, here we study signs of depression in male SAMP8 mice. For this purpose, we used the forced swimming test (FST). The total floating time in the FST was greater in SAMP8 than in SAMR1 mice at 9 months of age; however, this difference was not observed in 12-month-old mice, when both strains are considered elderly. Of the two strains, only the SAMP8 animals responded to imipramine treatment. We also applied the dexamethasone suppression test (DST) and studied changes in the dopamine and serotonin (5-HT) uptake systems, the 5-HT2a/2c receptor density in the cortex, and levels of TPH2. The DST showed a significant difference between SAMR1 and SAMP8 mice at old age. SAMP8 exhibits an increase in 5-HT transporter density, with slight changes in 5-HT2a/2c receptor density. In conclusion, SAMP8 mice presented depression-like behavior that is dependent on senescence process, because it differs from SAMR1, senescence resistant strain.
Note: Versió postprint del document publicat a:
It is part of: Biogerontology, 2013, vol. 14, num. 2, p. 165-176
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ISSN: 1389-5729
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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