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Title: Characterization of human pancreatic orthotopic tumor xenografts suitable for drug screening
Author: Pérez Torras, Sandra
Vidal Pla, Anna
Miquel Morera, Rosa
Almendro Navarro, Vanessa
Fernández-Cruz, Laureano
Navarro Colás, Salvador
Maurel Santasusana, Joan
Carbó Carbó, Neus
Gascón, Pere
Mazo Sánchez, Adela
Keywords: Càncer
Genètica molecular
Teràpia genètica
Molecular genetics
Gene therapy
Issue Date: 1-Nov-2011
Publisher: IOS Press
Abstract: Background Efforts to identify novel therapeutic options for human pancreatic ductal adenocarcinoma (PDAC) have failed to result in a clear improvement in patient survival to date. Pancreatic cancer requires efficient therapies that must be designed and assayed in preclinical models with improved predictor ability. Among the available preclinical models, the orthotopic approach fits with this expectation, but its use is still occasional. Methods An in vivo platform of 11 orthotopic tumor xenografts has been generated by direct implantation of fresh surgical material. In addition, a frozen tumorgraft bank has been created, ensuring future model recovery and tumor tissue availability. Results Tissue microarray studies allow showing a high degree of original histology preservation and maintenance of protein expression patterns through passages. The models display stable growth kinetics and characteristic metastatic behavior. Moreover, the molecular diversity may facilitate the identification of tumor subtypes and comparison of drug responses that complement or confirm information obtained with other preclinical models. Conclusions This panel represents a useful preclinical tool for testing new agents and treatment protocols and for further exploration of the biological basis of drug responses.
Note: Reproducció del document publicat a:
It is part of: Analytical Cellular Pathology / Cellular Oncology, 2011, vol. 34, num. 6, p. 511-521
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ISSN: 1570-5870
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Medicina)

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