Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/50383| Title: | Oligonucleotide cyclization: The thiol-maleimide reaction revisited |
| Author: | Sánchez-Moya, Albert Pedroso Muller, Enrique Grandas Sagarra, Anna |
| Keywords: | Bioquímica Àcids nucleics Bacteris Microbiologia Ciclització (Química) Biochemistry Nucleic acids Bacteria Microbiology Ring formation (Chemistry) |
| Issue Date: | 2013 |
| Publisher: | Royal Society of Chemistry |
| Abstract: | A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol-derivatized linear precursors. Retro-Diels-Alder conditions deprotecting the maleimide simultaneously promoted cyclization cleanly and in high yield. |
| Note: | Versió postprint del document publicat a: http://dx.doi.org/ 10.1039/C2CC35357A |
| It is part of: | Chemical Communications, 2013, vol. 49, p. 309-311 |
| URI: | http://hdl.handle.net/2445/50383 |
| Related resource: | http://dx.doi.org/10.1039/C2CC35357A |
| ISSN: | 1359-7345 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 619951.pdf | 321.21 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.