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Title: Oligonucleotide cyclization: The thiol-maleimide reaction revisited
Author: Sánchez, Albert
Pedroso Muller, Enrique
Grandas Sagarra, Anna
Keywords: Bioquímica
Àcids nucleics
Ciclització (Química)
Nucleic acids
Ring formation (Chemistry)
Issue Date: 2013
Publisher: Royal Society of Chemistry
Abstract: A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol-derivatized linear precursors. Retro-Diels-Alder conditions deprotecting the maleimide simultaneously promoted cyclization cleanly and in high yield.
Note: Versió postprint del document publicat a: 10.1039/C2CC35357A
It is part of: Chemical Communications, 2013, vol. 49, p. 309-311
Related resource:
ISSN: 1359-7345
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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