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Title: Modulation of plant HMG-CoA reductase by protein phosphatase 2A: Positive and negative control at a key node of metabolism
Author: Antolín Llovera, Meritxell
Leivar Rico, Pablo
Arró i Plans, Montserrat
Ferrer i Prats, Albert
Boronat i Margosa, Albert
Campos Martínez, Narciso
Keywords: Genètica vegetal
Proteïnes vegetals
Metabolisme de les plantes
Plant genetics
Plant proteins
Plant metabolism
Issue Date: Aug-2011
Publisher: Landes Bioscience
Abstract: The enzyme HMG-CoA reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis, critical not only for normal plant development, but also for the adaptation to demanding environmental conditions. Consistent with this notion, plant HMGR is modulated by many diverse endogenous signals and external stimuli. Protein phosphatase 2A (PP2A) is involved in auxin, abscisic acid, ethylene and brassinosteroid signaling and now emerges as a positive and negative multilevel regulator of plant HMGR, both during normal growth and in response to a variety of stress conditions. The interaction with HMGR is mediated by B" regulatory subunits of PP2A, which are also calcium binding proteins. The new discoveries uncover the potential of PP2A to integrate developmental and calcium-mediated environmental signals in the control of plant HMGR.
Note: Versió postprint del document publicat a:
It is part of: Plant Signaling and Behavior, 2011, vol. 6, num. 8, p. 1127 -1131
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ISSN: 1559-2316
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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