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Title: Changes in lipoprotein lipase modulate tissular energy supply during stress
Author: Ricart i Jané, David
Cejudo Martín, María del Pilar
Peinado Onsurbe, Julia
López Tejero, M. Dolores
Llobera i Sande, Miquel
Keywords: Lipoproteïnes
Teixit adipós
Rates (Animals de laboratori)
Efecte de l'estrès sobre els animals
Adipose tissues
Rats as laboratory animals
Effect of stress on animals
Issue Date: Oct-2005
Publisher: American Physiological Society
Abstract: We studied the variations caused by stress in lipoprotein lipase (LPL) activity, LPL-mRNA, and local blood flow in LPL-rich tissues in the rat. Stress was produced by body immobilization (Immo): the rat's limbs were taped to metal mounts, and its head was placed in a plastic tube. Chronic stress (2 h daily of Immo) decreased total LPL activity in mesenteric and epididymal white adipose tissue (WAT) and was accompanied by a weight reduction of these tissues. In limb muscle, heart, and adrenals, total LPL activity and mRNA levels increased, and, in plasma, LPL activity and mass also increased. Acute stress (30-min Immo) caused a decrease in total LPL activity only in retroperitoneal WAT and an increase in preheparin plasma active LPL, but the overall weight of this tissue did not vary significantly. We propose an early release of the enzyme from this tissue into the bloodstream by some unknown extracellular pathways or other local mechanisms. These changes in this key energy-regulating enzyme are probably induced by catecholamines. They modify the flow of energy substrates between tissues, switching the WAT from importer to exporter of free fatty acids and favoring the uptake by muscle of circulating triacylglycerides for energy supply. Moreover, we found that acute stress almost doubled blood flow in all WAT studied, favoring the export of free fatty acids.
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It is part of: Journal of Applied Physiology, 2005, num.
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ISSN: 8750-7587
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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