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Title: Nitric oxide and the release of lipoprotein lipase from white adipose tissue
Author: Ricart i Jané, David
Casanovas Torrequebrada, Albert
Jané, N.
González Junca, Alba
Buira Morell, Irma
Ribera, J.
Llobera i Sande, Miquel
López Tejero, M. Dolores
Keywords: Lipoproteïnes
Teixit adipós
Rates (Animals de laboratori)
Òxid nítric
Adipose tissues
Rats as laboratory animals
Nitric oxide
Issue Date: 2008
Publisher: Karger
Abstract: Background/Aim: Lipoprotein lipase (LPL) is the main enzyme responsible for the distribution of circulating triacylglycerides in tissues. Its regulation via release from active sites in the vascular endothelium is poorly understood. In a previous study we reported that in response to acute immobilization (IMMO), LPL activity rapidly increases in plasma and decreases in white adipose tissue (WAT) in rats. In other stress situations IMMO triggers a generalized increase in nitric oxide (NO) production. Methods/Results: Here we demonstrate that in rats: 1) in vivo acute IMMO rapidly increases NO concentrations in plasma 2) during acute IMMO the WAT probably produces NO via the endothelial isoform of nitric oxide synthase (eNOS) from vessels, and 3) epididymal WAT perfused in situ with an NO donor rapidly releases LPL from the endothelium. Conclusion: We propose the following chain of events: stress stimulus / rapid increase of NO production in WAT (by eNOS) / release of LPL from the endothelium in WAT vessels. This chain of events could be a new mechanism that promotes the rapid decrease of WAT LPL activity in response to a physiological stimulus.
Note: Reproducció del document publicat a:
It is part of: Cellular Physiology and Biochemistry, 2008, vol. 22, p. 525-530
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ISSN: 1015-8987
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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