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Title: Insulin dysfunction and allostic load in bipolar disorder
Author: Brietzke, Elisa
Kapczinski, Flávio
Grassi-Oliveira, Rodrigo
Grande i Fullana, Iria
Vieta i Pascual, Eduard, 1963-
McIntyre, Roger S.
Keywords: Trastorn bipolar
Estrès oxidatiu
Manic-depressive illness
Oxidative stress
Issue Date: Jul-2011
Publisher: Informa
Abstract: Bipolar disorder (BD) is associated with substantial morbidity, as well as premature mortality. Available evidence indicates that 'stress-sensitive' chronic medical disorders, such as cardiovascular disease, obesity and Type 2 diabetes mellitus, are critical mediators and/or moderators of BD. Changes in physiologic systems implicated in allostasis have been proposed to impact brain structures and neurocognition, as well as medical comorbidity in this population. For example, abnormalities in insulin physiology, for example, insulin resistance, hyperinsulinemia and central insulinopenia, are implicated as effectors of allostatic load in BD. Insulin's critical role in CNS physiological (e.g., neurotrophism and synaptic plasticity) and pathophysiological (e.g., neurocognitive deficits, pro-apoptosis and amyloid deposition) processes is amply documented. This article introduces the concept that insulin is a mediator of allostatic load in the BD and possibly a therapeutic target.
Note: Reproducció del document publicat a:
It is part of: Expert Review of Neurotherapeutics, 2011, vol. 11, num. 7, p. 1017-1028
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ISSN: 1473-7175
Appears in Collections:Articles publicats en revistes (Psicologia Clínica i Psicobiologia)

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