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Title: Is syndecan-2 a key angiogenic element?
Author: Noguer Serra, Josep Oriol
Reina del Pozo, Manuel
Keywords: Angiogènesi
Expressió gènica
Gene expression
Issue Date: 2009
Publisher: Hindawi
Abstract: Angiogenesis is a tightly regulated process in vertebrates that leads to the formation of new blood vessels from pre-existing vessels or by the recruitment of bone marrow-derived endothelial precursor cells[1]. During embryogenesis, after stimulation by proangiogenic factors, such as VEGF or FGF, it contributes to the maturation of the vascular plexus. In adults, it is important in some physiologic conditions, such as wound healing or the reproductive cycle in females, although most of the time it is"switched off" by endogenous inhibitors, such as endostatin or angiostatin. Furthermore, its misregulation is the cause of many pathological situations, as it contributes to tumor development[2], diabetic retinopathy[3], rheumatoid arthritis[4], psoriasis[5], but also cardiovascular disorders[6] and obesity[7]
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It is part of: Scientific World Journal, 2009, vol. 9
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ISSN: 1537-744X
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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