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Title: Antibiotic prophylaxis to prevent local infection in oral surgery: use or abuse?
Author: Sancho Puchades, Manuel
Herráez Vilas, José María
Berini Aytés, Leonardo
Gay Escoda, Cosme
Keywords: Cirurgia oral
Control d'infeccions
Medicina preventiva
Oral surgery
Infection control
Preventive medicine
Issue Date: 1-Jan-2009
Publisher: Medicina Oral SL
Abstract: Antibiotics have a well-documented efficacy in the treatment of established infections and as prophylactic agents in medically compromised patients. However, the systematic administration of antibiotics to prevent local infections in fit patients is much more controversial. The aim of this paper is to reflect on the justification for prophylactic usage of antibiotics to prevent wound infection and to reason out the most appropriate antibiotic guidelines taking into account available scientific data and studies by other authors. Numerous clinical trials question the efficacy of antibiotics in preventing wound infection. While some studies establish that antibiotics reduce the incidence of postoperative infections, others compare their efficacy to that of placebo. Thus, scientific literature suggests that every oral surgical intervention is not tributary of systematic antibiotic prophylaxis to prevent local infections. Intrinsic surgical risk factors and the patient"s individual circumstances must be taken into account. Even though the efficacy of other antibiotics cannot be ruled out due to our limited comprehension of the bacteriologic interrelations intervening in the pathogenesis of postextraction local infection, the amoxicillin-clavulanic acid combination theoretically covers the complete odontogenic bacterial spectrum in Spain. When the prophylactic use of antibiotics is indicated, this should be performed preoperatively, at high doses, and its extent should not exceed 24 hours. Special attention should be paid to antiinfectious local measures that can minimize infection risk during the wound"s healing period
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It is part of: Medicina Oral, Patología Oral y Cirugia Bucal, 2009, vol. 14, num. 1, p. 28-33
ISSN: 1698-4447
Appears in Collections:Articles publicats en revistes (Odontostomatologia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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