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Title: Evaluation of a pharmacist intervention on patients initiating pharmacological treatment for depression: a randomized controlled superiority trial
Author: Rubio Valera, Maria
March Pujol, Marian
Fernández Sánchez, Ana
Peñarrubia María, María Teresa
Travé i Mercadé, Pere
López del Hoyo, Yolanda
Serrano Blanco, Antoni
Keywords: Depressió psíquica
Serveis farmacèutics
Cooperació dels malalts
Atenció primària
Assaigs clínics
Mental depression
Pharmaceutical services
Patient compliance
Primary health care
Clinical trials
Issue Date: 23-Sep-2013
Publisher: Elsevier B.V.
Abstract: Major depression is associated with high burden, disability and costs. Non-adherence limits the effectiveness of antidepressants. Community pharmacists (CP) are in a privileged position to help patients cope with antidepressant treatment. The aim of the study was to evaluate the impact of a CP intervention on primary care patients who had initiated antidepressant treatment. Newly diagnosed primary care patients were randomised to usual care (UC) (92) or pharmacist intervention (87). Patients were followed up at 6 months and evaluated three times (Baseline, and at 3 and 6 months). Outcome measurements included clinical severity of depression (PHQ-9), health-related quality of life (HRQOL) (Euroqol-5D) and satisfaction with pharmacy care. Adherence was continuously registered from the computerised pharmacy records. Non-adherence was defined as refilling less than 80% of doses or having a medication-free gap of more than 1 month. Patients in the intervention group were more likely to remain adherent at 3 and 6 months follow-up but the difference was not statistically significant. Patients in the intervention group showed greater statistically significant improvement in HRQOL compared with UC patients both in the main analysis and PP analyses. No statistically significant differences were observed in clinical symptoms or satisfaction with the pharmacy service. The results of our study indicate that a brief intervention in community pharmacies does not improve depressed patients' adherence or clinical symptoms. This intervention helped patients to improve their HRQOL, which is an overall measure of patient status.
Note: Versió postprint del document publicat a:
It is part of: European Neuropsychopharmacology, 2013, vol. 23, num. 9, p. 1057-1066
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ISSN: 0924-977X
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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