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Title: Identification of metabolites and thermal transformation products of quinolones in raw cow milk by liquid chromatography coupled to high resolution mass spectrometry.
Author: Junza Martínez, Alexandra
Barbosa, S.
Codony Salcedo, Rafael
Jubert, A.
Barbosa Torralbo, José
Barrón Bueno, Dolores
Keywords: Metabòlits
Cromatografia de líquids
Espectrometria de masses
Tractament tèrmic
Quinolone antibacterial agents
Liquid chromatography
Mass spectrometry
Heat treatment
Issue Date: 5-Feb-2014
Publisher: American Chemical Society, Books and Journals Division]
Abstract: The presence of residues of antibiotics, metabolites, and thermal transformation products (TPs), produced during thermal treatment to eliminate pathogenic microorganisms in milk, could represent a risk for people. Cow"s milk samples spiked with enrofloxacin (ENR), ciprofloxacin (CIP), difloxacin (DIF), and sarafloxacin (SAR) and milk samples from cows medicated with ENR were submitted to several thermal treatments. The milk samples were analyzed by liquid chromatography-mass spectrometry (LC-MS) to find and identify TPs and metabolites. In this work, 27 TPs of 4 quinolones and 24 metabolites of ENR were found. Some of these compounds had been reported previously, but others were characterized for the first time, including lactose-conjugated CIP, the formamidation reaction for CIP and SAR, and hydroxylation or ketone formation to produce three different isomers for all quinolones studied.
Note: Versió postprint del document publicat a:
It is part of: Journal of Agricultural and Food Chemistry, 2014, vol. 62, num. 8, p. 2008-2021
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ISSN: 0021-8561
Appears in Collections:Articles publicats en revistes (Enginyeria Química i Química Analítica)

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