Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/52827
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Navarro Ponz, Alfons | - |
dc.contributor.author | Muñoz, Carmen | - |
dc.contributor.author | Gaya, Anna | - |
dc.contributor.author | Díaz Beyà, Marina | - |
dc.contributor.author | Gel, Bernat | - |
dc.contributor.author | Tejero Villalba, Rut | - |
dc.contributor.author | Díaz Sánchez, Tania | - |
dc.contributor.author | Martínez Pozo, Antonio | - |
dc.contributor.author | Monzó Planella, Mariano | - |
dc.date.accessioned | 2014-03-24T09:27:41Z | - |
dc.date.available | 2014-03-24T09:27:41Z | - |
dc.date.issued | 2013-05-21 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/52827 | - |
dc.description.abstract | Background: In recent years, microRNA (miRNA) pathways have emerged as a crucial system for the regulation of tumorogenesis. miR-SNPs are a novel class of single nucleotide polymorphisms that can affect miRNA pathways. Design and Methods: We analyzed eight miR-SNPs by allelic discrimination in 141 patients with Hodgkin lymphoma and correlated the results with treatment-related toxicity, response, disease-free survival (DFS) and overall survival (OS). Results: The KRT81 (rs3660) GG genotype was associated with an increased risk of neurological toxicity (P=0.016), while patients with XPO5 (rs11077) AA or CC genotypes had a higher rate of bleomycin-associated pulmonary toxicity (P=0.048). Both miR-SNPs emerged as independent factors in the multivariate analysis. The XPO5 AA and CC genotypes were also associated with a lower response rate (P=0.036). XPO5 (P=0.039) and TRBP (rs784567) (P=0.022) genotypes emerged as prognostic markers for DFS, and XPO5 was also associated with OS (P=0.033). In the multivariate analysis, only XPO5 emerged as an independent prognostic factor for DFS (HR: 2.622; 95%CI 1.039-6.620; P=0.041). Given the influence of XPO5 and TRBP as individual markers, we then investigated the combined effect of these miR-SNPs. Patients with both the XPO5 AA/CC and TRBP TT/TC genotypes had the shortest DFS (P=0.008) and OS (P=0.008). Conclusion: miR-SNPs can add useful prognostic information on treatment-related toxicity and clinical outcome in Hodgkin lymphoma and can be used to identify patients likely to be chemoresistant or to relapse. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0064716 | - |
dc.relation.ispartof | PLoS One, 2013, vol. 8, num. 5, p. e64716 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0064716 | - |
dc.rights | cc-by (c) Navarro Ponz, Alfons et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Malaltia de Hodgkin | - |
dc.subject.classification | Micro RNAs | - |
dc.subject.classification | Limfomes | - |
dc.subject.other | Hodgkin's disease | - |
dc.subject.other | MicroRNAs | - |
dc.subject.other | Lymphomas | - |
dc.title | MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin Lymphoma patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 624379 | - |
dc.date.updated | 2014-03-24T09:27:41Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23705004 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
624379.pdf | 332.13 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License