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Title: Asymmetric stochastic switching driven by intrinsic molecular noise
Author: Frigola, David
Casanellas Vilageliu, Laura
Sancho, José M.
Ibañes Miguez, Marta
Keywords: Fenotip
Equació de Fokker-Planck
Dinàmica molecular
Processos estocàstics
Diferenciació cel·lular
Fokker-Planck equation
Molecular dynamics
Stochastic processes
Cell diferentiation
Issue Date: 21-Feb-2012
Publisher: Public Library of Science (PLoS)
Abstract: Low-copy-number molecules are involved in many functions in cells. The intrinsic fluctuations of these numbers can enable stochastic switching between multiple steady states, inducing phenotypic variability. Herein we present a theoretical and computational study based on Master Equations and Fokker-Planck and Langevin descriptions of stochastic switching for a genetic circuit of autoactivation. We show that in this circuit the intrinsic fluctuations arising from low-copy numbers, which are inherently state-dependent, drive asymmetric switching. These theoretical results are consistent with experimental data that have been reported for the bistable system of the gallactose signaling network in yeast. Our study unravels that intrinsic fluctuations, while not required to describe bistability, are fundamental to understand stochastic switching and the dynamical relative stability of multiple states.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2012, vol. 7, num. 2, p. e31407
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Física Quàntica i Astrofísica)

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