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http://hdl.handle.net/2445/52919
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DC Field | Value | Language |
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dc.contributor.author | Vilà Prats, Laia | - |
dc.contributor.author | Roglans i Ribas, Núria | - |
dc.contributor.author | Baena Muñoz, Miguel | - |
dc.contributor.author | Barroso Fernández, Emma | - |
dc.contributor.author | Alegret i Jordà, Marta | - |
dc.contributor.author | Merlos Roca, Manuel | - |
dc.contributor.author | Laguna Egea, Juan Carlos | - |
dc.date.accessioned | 2014-03-24T17:42:31Z | - |
dc.date.available | 2014-03-24T17:42:31Z | - |
dc.date.issued | 2012-12-04 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/52919 | - |
dc.description.abstract | Although metabolic syndrome (MS) and systemic lupus erythematosus (SLE) are often associated, a common link has not been identified. Using the BWF1 mouse, which develops MS and SLE, we sought a molecular connection to explain the prevalence of these two diseases in the same individuals. We determined SLE- markers (plasma anti-ds-DNA antibodies, splenic regulatory T cells (Tregs) and cytokines, proteinuria and renal histology) and MS-markers (plasma glucose, non-esterified fatty acids, triglycerides, insulin and leptin, liver triglycerides, visceral adipose tissue, liver and adipose tissue expression of 86 insulin signaling-related genes) in 8-, 16-, 24-, and 36-week old BWF1 and control New-Zealand-White female mice. Up to week 16, BWF1 mice showed MS-markers (hyperleptinemia, hyperinsulinemia, fatty liver and visceral adipose tissue) that disappeared at week 36, when plasma anti-dsDNA antibodies, lupus nephritis and a pro-autoimmune cytokine profile were detected. BWF1 mice had hyperleptinemia and high splenic Tregs till week 16, thereby pointing to leptin resistance, as confirmed by the lack of increased liver P-Tyr-STAT-3. Hyperinsulinemia was associated with a down-regulation of insulin related-genes only in adipose tissue, whereas expression of liver mammalian target of rapamicyn (mTOR) was increased. Although leptin resistance presented early in BWF1 mice can slow-down the progression of autoimmunity, our results suggest that sustained insulin stimulation of organs, such as liver and probably kidneys, facilitates the over-expression and activity of mTOR and the development of SLE. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0051118 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 12, p. e51118 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0051118 | - |
dc.rights | cc-by (c) Vilà Prats, Laia et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Lupus eritematós | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.classification | Malalties del fetge | - |
dc.subject.classification | Síndrome metabòlica | - |
dc.subject.classification | Proteïnes quinases | - |
dc.subject.classification | Citoquines | - |
dc.subject.classification | Ratolins (Animals de laboratori) | - |
dc.subject.other | Lupus erythematosus | - |
dc.subject.other | Autoimmune diseases | - |
dc.subject.other | Liver diseases | - |
dc.subject.other | Metabolic syndrome | - |
dc.subject.other | Protein kinases | - |
dc.subject.other | Cytokines | - |
dc.subject.other | Mice (Laboratory animals) | - |
dc.title | Metabolic alterations and increased liver mTOR expression precede the development of autoimmune disease in a murine model of lupus erythematosus | eng |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 618414 | - |
dc.date.updated | 2014-03-24T17:42:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23226562 | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) Articles publicats en revistes (Institut de Biomedicina (IBUB)) |
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618414.pdf | 654.12 kB | Adobe PDF | View/Open |
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