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Title: | An integrative computational analysis provides evidence for FBN1-associated network deregulation in trisomy 21 |
Author: | Vilardell, Mireia Civit Vives, Sergi Herwig, R. |
Keywords: | Síndrome de Down Genètica Malalties coronàries Bioinformàtica Down syndrome Genetics Coronary diseases Bioinformatics |
Issue Date: | 25-Jun-2013 |
Publisher: | Bentham Open |
Abstract: | Although approximately 50% of Down Syndrome (DS) patients have heart abnormalities, they exhibit an overprotection against cardiac abnormalities related with the connective tissue, for example a lower risk of coronary artery disease. A recent study reported a case of a person affected by DS who carried mutations in FBN1, the gene causative for a connective tissue disorder called Marfan Syndrome (MFS). The fact that the person did not have any cardiac alterations suggested compensation effects due to DS. This observation is supported by a previous DS meta-analysis at the molecular level where we have found an overall upregulation of FBN1 (which is usually downregulated in MFS). Additionally, that result was cross-validated with independent expression data from DS heart tissue. The aim of this work is to elucidate the role of FBN1 in DS and to establish a molecular link to MFS and MFS-related syndromes using a computational approach. To reach that, we conducted different analytical approaches over two DS studies (our previous meta-analysis and independent expression data from DS heart tissue) and revealed expression alterations in the FBN1 interaction network, in FBN1 co-expressed genes and FBN1-related pathways. After merging the significant results from different datasets with a Bayesian approach, we prioritized 85 genes that were able to distinguish control from DS cases. We further found evidence for several of these genes (47%), such as FBN1, DCN, and COL1A2, being dysregulated in MFS and MFS-related diseases. Consequently, we further encourage the scientific community to take into account FBN1 and its related network for the study of DS cardiovascular characteristics. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1242/bio.20134408 |
It is part of: | The Open Biology Journal, 2013, vol. 2, p. 771-778 |
URI: | http://hdl.handle.net/2445/52997 |
Related resource: | http://dx.doi.org/10.1242/bio.20134408 |
ISSN: | 1874-1967 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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