Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/53007
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dc.contributor.authorDomenech Pena, Arnau-
dc.contributor.authorArdanuy Tisaire, María Carmen-
dc.contributor.authorPallarés Giner, Roman-
dc.contributor.authorGrau, Immaculada-
dc.contributor.authorSantos Pérez, Salud-
dc.contributor.authorCampa, Adela G. de la-
dc.contributor.authorLiñares Louzao, Josefina-
dc.date.accessioned2014-03-26T13:02:15Z-
dc.date.available2014-03-26T13:02:15Z-
dc.date.issued2013-03-11-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/2445/53007-
dc.description.abstractObjectives: To analyze the role of the capsular type in pneumococci causing relapse and reinfection episodes of acute exacerbation in COPD patients. Methods: A total of 79 patients with 116 recurrent episodes of acute exacerbations caused by S. pneumoniae were included into this study (1995–2010). A relapse episode was considered when two consecutive episodes were caused by the same strain (identical serotype and genotype); otherwise it was considered reinfection. Antimicrobial susceptibility testing (microdilution), serotyping (PCR, Quellung) and molecular typing (PFGE/MLST) were performed. Results: Among 116 recurrent episodes, 81 (69.8%) were reinfections, caused by the acquisition of a new pneumococcus, and 35 (30.2%) were relapses, caused by a pre-existing strain. Four serotypes (9V, 19F, 15A and 11A) caused the majority (60.0%) of relapses. When serotypes causing relapses and reinfection were compared, only two serotypes were associated with relapses: 9V (OR 8.0; 95% CI, 1.34–85.59) and 19F (OR 16.1; 95% CI, 1.84–767.20). Pneumococci isolated from relapses were more resistant to antimicrobials than those isolated from the reinfection episodes: penicillin (74.3% vs. 34.6%, p,0.001), ciprofloxacin (25.7% vs. 9.9%, p,0.027), levofloxacin (22.9% vs. 7.4%, p = 0.029), and co-trimoxazole (54.3% vs. 25.9%, p,0.001). Conclusions: Although the acquisition of a new S. pneumoniae strain was the most frequent cause of recurrences, a third of the recurrent episodes were caused by a pre-existing strain. These relapse episodes were mainly caused by serotypes 9V and 19F, suggesting an important role for capsular type-
dc.format.extent4 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherPublic Library of Science (PLoS)-
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0059027-
dc.relation.ispartofPLoS One, 2013, vol. 8, num. 3, p. 1-4-
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0059027-
dc.rightscc-by (c) Domènech, Arnau et al., 2013-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)-
dc.subject.classificationMalalties pulmonars obstructives cròniques-
dc.subject.classificationInfeccions per pneumococs-
dc.subject.otherChronic obstructive pulmonary diseases-
dc.subject.otherPneumococcal Infections-
dc.titleSome pneumococcal serotypes are more frequently associated with relapses of acute exacerbations in COPD patients-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec620928-
dc.date.updated2014-03-26T13:02:15Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid23536850-
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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