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DC Field | Value | Language |
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dc.contributor.author | Domenech Pena, Arnau | - |
dc.contributor.author | Ardanuy Tisaire, María Carmen | - |
dc.contributor.author | Pallarés Giner, Roman | - |
dc.contributor.author | Grau, Immaculada | - |
dc.contributor.author | Santos Pérez, Salud | - |
dc.contributor.author | Campa, Adela G. de la | - |
dc.contributor.author | Liñares Louzao, Josefina | - |
dc.date.accessioned | 2014-03-26T13:02:15Z | - |
dc.date.available | 2014-03-26T13:02:15Z | - |
dc.date.issued | 2013-03-11 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/53007 | - |
dc.description.abstract | Objectives: To analyze the role of the capsular type in pneumococci causing relapse and reinfection episodes of acute exacerbation in COPD patients. Methods: A total of 79 patients with 116 recurrent episodes of acute exacerbations caused by S. pneumoniae were included into this study (1995–2010). A relapse episode was considered when two consecutive episodes were caused by the same strain (identical serotype and genotype); otherwise it was considered reinfection. Antimicrobial susceptibility testing (microdilution), serotyping (PCR, Quellung) and molecular typing (PFGE/MLST) were performed. Results: Among 116 recurrent episodes, 81 (69.8%) were reinfections, caused by the acquisition of a new pneumococcus, and 35 (30.2%) were relapses, caused by a pre-existing strain. Four serotypes (9V, 19F, 15A and 11A) caused the majority (60.0%) of relapses. When serotypes causing relapses and reinfection were compared, only two serotypes were associated with relapses: 9V (OR 8.0; 95% CI, 1.34–85.59) and 19F (OR 16.1; 95% CI, 1.84–767.20). Pneumococci isolated from relapses were more resistant to antimicrobials than those isolated from the reinfection episodes: penicillin (74.3% vs. 34.6%, p,0.001), ciprofloxacin (25.7% vs. 9.9%, p,0.027), levofloxacin (22.9% vs. 7.4%, p = 0.029), and co-trimoxazole (54.3% vs. 25.9%, p,0.001). Conclusions: Although the acquisition of a new S. pneumoniae strain was the most frequent cause of recurrences, a third of the recurrent episodes were caused by a pre-existing strain. These relapse episodes were mainly caused by serotypes 9V and 19F, suggesting an important role for capsular type | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0059027 | - |
dc.relation.ispartof | PLoS One, 2013, vol. 8, num. 3, p. 1-4 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0059027 | - |
dc.rights | cc-by (c) Domènech, Arnau et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.classification | Infeccions per pneumococs | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.subject.other | Pneumococcal Infections | - |
dc.title | Some pneumococcal serotypes are more frequently associated with relapses of acute exacerbations in COPD patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 620928 | - |
dc.date.updated | 2014-03-26T13:02:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23536850 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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620928.pdf | 139.05 kB | Adobe PDF | View/Open |
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