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http://hdl.handle.net/2445/53208
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DC Field | Value | Language |
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dc.contributor.author | Bosch Hereu, Lluís | - |
dc.contributor.author | Cialîcu, Ionela | - |
dc.contributor.author | Caner, Joaquim | - |
dc.contributor.author | Ariza Piquer, Xavier | - |
dc.contributor.author | Costa i Arnau, Anna M. | - |
dc.contributor.author | Terrazas Martínez, Montserrat | - |
dc.contributor.author | Vilarrasa i Llorens, Jaume | - |
dc.date.accessioned | 2014-04-03T08:45:22Z | - |
dc.date.available | 2014-04-03T08:45:22Z | - |
dc.date.issued | 2012-03-14 | - |
dc.identifier.issn | 0040-4039 | - |
dc.identifier.uri | http://hdl.handle.net/2445/53208 | - |
dc.description.abstract | Pd-catalysed reactions of 2-Cl, 2-Br and 2-I derivatives of a 6-chloropurine nucleoside with benzamide have been compared, using Pd2dba3, Xantphos and Cs2CO3 in toluene, between 20 and 80 °C. The reactivity order was 2-I > 2-Br > 6-Cl ≫ 2-Cl. The 2-I substituent could be replaced even at 0 °C, under conditions disclosed here for the first time. On the other hand, the replacement of the chlorine atom at position 2 (2-Cl) required 110 °C. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.tetlet.2012.01.012 | - |
dc.relation.ispartof | Tetrahedron Letters, 2012, vol. 53, num. 11, p. 1358-1362 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.tetlet.2012.01.012 | - |
dc.rights | (c) Elsevier Ltd, 2012 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Àcids nucleics | - |
dc.subject.classification | Compostos heterocíclics | - |
dc.subject.classification | Citotoxicitat per mediació cel·lular | - |
dc.subject.classification | Nucleòsids | - |
dc.subject.classification | Medicaments antineoplàstics | - |
dc.subject.other | Nucleic acids | - |
dc.subject.other | Heterocyclic compounds | - |
dc.subject.other | Cell-mediated cytotoxicity | - |
dc.subject.other | Nucleosides | - |
dc.subject.other | Antineoplastic agents | - |
dc.title | Pd-catalysed amidation of 2,6-dihalopurine nucleosides. Replacement of iodine at 0 ºC | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 605786 | - |
dc.date.updated | 2014-04-03T08:45:22Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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605786.pdf | 366.01 kB | Adobe PDF | View/Open |
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