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Title: Protracted treatment with MDMA induces heteromeric nicotinic receptor up-regulation in rat brain: an autoradiography study.
Author: Ciudad Roberts, Andrés
Camarasa García, Jordi
Escubedo Rafa, Elena
Pubill Sánchez, David
Keywords: Compostos heterocíclics
Èxtasi (Droga)
Receptors nicotínics
Rates (Animals de laboratori)
Heterocyclic compounds
Ecstasy (Drug)
Nicotinic receptors
Rats as laboratory animals
Issue Date: 12-Mar-2014
Publisher: Elsevier B.V.
Abstract: Previous studies indicate that 3,4-methylenedioxy-methamphetamine (MDMA, ecstasy) can induce heteromeric nicotinic acetylcholine receptor (nAChR, mainly of α4β2 subtype) up-regulation. In this study we treated Sprague-Dawley rats twice-daily for 10 days with either saline or MDMA (7 mg/kg) and killed them on day 11 to perform [125I]epibatidine binding autoradiograms on serial coronal slices. Results showed significant increases in nAChR density in the substantia nigra, ventral tegmental area, nucleus accumbens, olfactory tubercle, anterior caudate-putamen, somatosensory cortex, motor cortex, auditory cortex, retrosplenial cortex, laterodorsal thalamus nuclei, amygdala, postsubiculum and pontine nuclei. These increases ranged from 3% (retrosplenial cortex) to 30 and 33% (amygdala and substantia nigra). No increased α4 subunit immunoreactivity was found in up-regulated areas compared with saline-treated rats, suggesting a post-translational mechanism as occurs with nicotine. The percentage of up-regulation correlated positively with the density of serotonin transporters, according to the serotonergic profile of MDMA. The heteromeric nAChR increase in concrete areas could account, at least in part, for the reinforcing, sensitizing and psychiatric disorders observed after long-term treatment with MDMA.
Note: Versió postprint del document publicat a:
It is part of: Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2014, vol. 53, p. 1-8
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ISSN: 0278-5846
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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