Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/53300
Title: Patterns of nucleotide diversity at the regions encompassing the Drosophila insulin-like peptide (dilp) genes: demography vs positive selection in Drosophila melanogaster.
Author: Guirao Rico, Sara
Aguadé Porres, Montserrat
Keywords: Genètica del desenvolupament
Genètica evolutiva
Evolució molecular
Transducció de senyal cel·lular
Insulina
Drosòfila melanogaster
Developmental genetics
Evolutionary genetics
Molecular evolution
Cellular signal transduction
Insulin
Drosophila melanogaster
Issue Date: 7-Jan-2013
Publisher: Public Library of Science (PLoS)
Abstract: In Drosophila, the insulin-signaling pathway controls some life history traits, such as fertility and lifespan, and it is considered to be the main metabolic pathway involved in establishing adult body size. Several observations concerning variation in body size in the Drosophila genus are suggestive of its adaptive character. Genes encoding proteins in this pathway are, therefore, good candidates to have experienced adaptive changes and to reveal the footprint of positive selection. The Drosophila insulin-like peptides (DILPs) are the ligands that trigger the insulin-signaling cascade. In Drosophila melanogaster, there are several peptides that are structurally similar to the single mammalian insulin peptide. The footprint of recent adaptive changes on nucleotide variation can be unveiled through the analysis of polymorphism and divergence. With this aim, we have surveyed nucleotide sequence variation at the dilp1-7 genes in a natural population of D. melanogaster. The comparison of polymorphism in D. melanogaster and divergence from D. simulans at different functional classes of the dilp genes provided no evidence of adaptive protein evolution after the split of the D. melanogaster and D. simulans lineages. However, our survey of polymorphism at the dilp gene regions of D. melanogaster has provided some evidence for the action of positive selection at or near these genes. The regions encompassing the dilp1-4 genes and the dilp6 gene stand out as likely affected by recent adaptive events.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0053593
It is part of: PLoS One, 2013, vol. 8, num. 1, p. e53593
Related resource: http://dx.doi.org/10.1371/journal.pone.0053593
URI: http://hdl.handle.net/2445/53300
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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