Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/53327
Title: Relation between plaque type, plaque thickness, blood shear stress, and plaque stress in coronary arteries assessed by X-ray Angiography and Intravascular Ultrasound
Author: Balocco, Simone
Gatta, Carlo
Alberti, Marina
Carrillo, Xavier
Rigla, Juan
Radeva, Petia
Keywords: Imatges mèdiques
Ultrasons en medicina
Vasos sanguinis
Imaging systems in medicine
Ultrasonics in medicine
Blood vessels
Issue Date: Dec-2012
Publisher: American Association of Physicists in Medicine
Abstract: Purpose: Atheromatic plaque progression is affected, among others phenomena, by biomechanical, biochemical, and physiological factors. In this paper, the authors introduce a novel framework able to provide both morphological (vessel radius, plaque thickness, and type) and biomechanical (wall shear stress and Von Mises stress) indices of coronary arteries. Methods: First, the approach reconstructs the three-dimensional morphology of the vessel from intravascular ultrasound(IVUS) and Angiographic sequences, requiring minimal user interaction. Then, a computational pipeline allows to automatically assess fluid-dynamic and mechanical indices. Ten coronary arteries are analyzed illustrating the capabilities of the tool and confirming previous technical and clinical observations. Results: The relations between the arterial indices obtained by IVUS measurement and simulations have been quantitatively analyzed along the whole surface of the artery, extending the analysis of the coronary arteries shown in previous state of the art studies. Additionally, for the first time in the literature, the framework allows the computation of the membrane stresses using a simplified mechanical model of the arterial wall. Conclusions: Circumferentially (within a given frame), statistical analysis shows an inverse relation between the wall shear stress and the plaque thickness. At the global level (comparing a frame within the entire vessel), it is observed that heavy plaque accumulations are in general calcified and are located in the areas of the vessel having high wall shear stress. Finally, in their experiments the inverse proportionality between fluid and structural stresses is observed.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1118/1.4760993
It is part of: Medical Physics, 2012, vol. 39, num. 12, p. 7430-7445
Related resource: http://dx.doi.org/10.1118/1.4760993
URI: http://hdl.handle.net/2445/53327
ISSN: 0094-2405
Appears in Collections:Articles publicats en revistes (Matemàtiques i Informàtica)

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