Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/53453
Title: Uncovering the functional constraints underlying the genomic organisation of the Odorant-Binding Protein genes
Author: Librado Sanz, Pablo
Rozas Liras, Julio A.
Keywords: Genòmica
Olfacte
Nucleòtids
Genètica del desenvolupament
Genomics
Smell
Nucleotides
Developmental genetics
Issue Date: Oct-2013
Publisher: Oxford University Press
Abstract: Animal olfactory systems have a critical role for the survival and reproduction of individuals. In insects, the odorant-binding proteins (OBPs) are encoded by a moderately sized gene family, and mediate the first steps of the olfactory processing. Most OBPs are organized in clusters of a few paralogs, which are conserved over time. Currently, the biological mechanism explaining the close physical proximity among OBPs is not yet established. Here, we conducted a comprehensive study aiming to gain insights into the mechanisms underlying the OBP genomic organization. We found that the OBP clusters are embedded within large conserved arrangements. These organizations also include other non-OBP genes, which often encode proteins integral to plasma membrane. Moreover, the conservation degree of such large clusters is related to the following: 1) the promoter architecture of the confined genes, 2) a characteristic transcriptional environment, and 3) the chromatin conformation of the chromosomal region. Our results suggest that chromatin domains may restrict the location of OBP genes to regions having the appropriate transcriptional environment, leading to the OBP cluster structure. However, the appropriate transcriptional environment for OBP and the other neighbor genes is not dominated by reduced levels of expression noise. Indeed, the stochastic fluctuations in the OBP transcript abundance may have a critical role in the combinatorial nature of the olfactory coding process.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1093/gbe/evt158
It is part of: Genome Biology and Evolution, 2013, vol. 5, num. 11, p. 2096-2108
Related resource: http://dx.doi.org/10.1093/gbe/evt158
URI: http://hdl.handle.net/2445/53453
ISSN: 1759-6653
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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