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Title: Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availability
Author: Sabater Martínez, David
Agnelli, Silvia
Arriarán, Sofía
Fernández López, José Antonio
Romero Romero, María del Mar
Alemany, Marià, 1946-
Remesar Betlloch, Xavier
Keywords: Síndrome metabòlica
Rates (animals de laboratori)
Metabolic syndrome
Amino acids
Rats as laboratory animals
Issue Date: 24-Feb-2014
Publisher: Hindawi Publishing Corporation
Abstract: Hyperlipidic diets limit glucose oxidation and favor amino acid preservation, hampering the elimination of excess dietary nitrogen and the catabolic utilization of amino acids.We analyzed whether reduced urea excretion was a consequence of higherNO𝑥; (nitrite,nitrate, and other derivatives) availability caused by increased nitric oxide production in metabolic syndrome. Rats fed a cafeteria diet for 30 days had a higher intake and accumulation of amino acid nitrogen and lower urea excretion.There were no differences in plasma nitrate or nitrite. NO𝑥 and creatinine excretion accounted for only a small part of total nitrogen excretion. Rats fed a cafeteria diet had higher plasma levels of glutamine, serine, threonine, glycine, and ornithinewhen comparedwith controls,whereas arginine was lower. Liver carbamoyl-phosphate synthetase I activity was higher in cafeteria diet-fed rats, but arginase I was lower. The high carbamoyl-phosphate synthetase activity and ornithine levels suggest activation of the urea cycle in cafeteria diet-fed rats, but low arginine levels point to a block in the urea cycle between ornithine and arginine, thereby preventing the elimination of excess nitrogen as urea. The ultimate consequence of this paradoxical block in the urea cycle seems to be the limitation of arginine production and/or availability.
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It is part of: BioMed Research International, 2014, vol. 2014
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ISSN: 2314-6133
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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