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Title: Patient with hepatocellular carcinoma related to prior acute arsenic intoxication and occult HBV: epidemiological, clinical and therapeutic results after 14 years of follow-up
Author: Casanovas Taltavull, Teresa
Ribes Puig, Josepa
Berrozpe, Ana
Jordan, Sara
Casanova Rituerto, Aurora
Sancho, Concha
Valls Duran, Carlos
Bosch, F. Xavier
Keywords: Càncer de fetge
Liver cancer
Issue Date: Mar-2006
Publisher: Baishideng Publishing Group
Abstract: Little is known about the long-term survivors of acute arsenic intoxication. We present here a clinical case report of a man with chronic hepatitis B virus (HBV) infection who developed hepatocellular carcinoma four years after acute arsenic poisoning. HBsAg was detected in serum in 1990 when he voluntarily donated blood. In 1991, the patient suffered from severe psychological depression that led him to attempt suicide by massive ingestion of an arsenic-containing rodenticide. He survived with polyneuropathy and paralysis of the lower limbs, and has been wheelchair-bound since then. During participation in a follow-up study conducted among HBV carriers, abdominal ultrasound detected a two-centimeter liver mass consistent with hepatocellular carcinoma. The tumor was confirmed by computed tomography (CT) and magnetic resonance image (MRI). Because of his significant comorbidity, the patient received palliative treatment with transarterial lipiodol chemoembolization (TACE) on three occasions (1996, 1997 and 1999). At his most recent visit in May 2005, the patient was asymptomatic, liver enzymes were normal and the tumor was in remission on ultrasound.
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It is part of: World Journal of Gastroenterology, 2006, vol. 12, num. 12, p. 1972-1974
ISSN: 1007-9327
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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