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Title: Orthogonal protection of peptides and peptoids for cyclization by the thiol-ene reaction and conjugation
Author: Elduque Busquets, Xavier
Pedroso Muller, Enrique
Grandas Sagarra, Anna
Keywords: Pèptids
Àcids nucleics
Ciclització (Química)
Nucleic acids
Ring formation (Chemistry)
Amino acids
Issue Date: 11-Mar-2014
Publisher: American Chemical Society
Abstract: Cyclic peptides and peptoids were prepared using the thiol-ene Michael-type reaction. The linear precursors were provided with additional functional groups allowing for subsequent conjugation: an orthogonally protected thiol, a protected maleimide, or an alkyne. The functional group for conjugation was placed either within the cycle or in an external position. The click reactions employed for conjugation with suitably derivatized nucleoside or oligonucleotides were either cycloadditions (Diels-Alder, Cu(I)-catalyzed azide-alkyne) or the same Michael-type reaction as for cyclization.
Note: Versió postprint del document publicat a:
It is part of: Journal of Organic Chemistry, 2014, vol. 79, num. 7, p. 2843-2853
Related resource:
ISSN: 0022-3263
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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