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http://hdl.handle.net/2445/53528
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DC Field | Value | Language |
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dc.contributor.author | Elduque Busquets, Xavier | - |
dc.contributor.author | Pedroso Muller, Enrique | - |
dc.contributor.author | Grandas Sagarra, Anna | - |
dc.date.accessioned | 2014-04-22T09:55:44Z | - |
dc.date.available | 2015-12-31T23:01:52Z | - |
dc.date.issued | 2014-03-11 | - |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | http://hdl.handle.net/2445/53528 | - |
dc.description.abstract | Cyclic peptides and peptoids were prepared using the thiol-ene Michael-type reaction. The linear precursors were provided with additional functional groups allowing for subsequent conjugation: an orthogonally protected thiol, a protected maleimide, or an alkyne. The functional group for conjugation was placed either within the cycle or in an external position. The click reactions employed for conjugation with suitably derivatized nucleoside or oligonucleotides were either cycloadditions (Diels-Alder, Cu(I)-catalyzed azide-alkyne) or the same Michael-type reaction as for cyclization. | - |
dc.format.extent | 36 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1021/jo500427c | - |
dc.relation.ispartof | Journal of Organic Chemistry, 2014, vol. 79, num. 7, p. 2843-2853 | - |
dc.relation.uri | http://dx.doi.org/10.1021/jo500427c | - |
dc.rights | (c) American Chemical Society , 2014 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Pèptids | - |
dc.subject.classification | Àcids nucleics | - |
dc.subject.classification | Ciclització (Química) | - |
dc.subject.classification | Aminoàcids | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | Peptides | - |
dc.subject.other | Nucleic acids | - |
dc.subject.other | Ring formation (Chemistry) | - |
dc.subject.other | Amino acids | - |
dc.subject.other | Proteins | - |
dc.title | Orthogonal protection of peptides and peptoids for cyclization by the thiol-ene reaction and conjugation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 639769 | - |
dc.date.updated | 2014-04-10T10:41:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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639769.pdf | 1.11 MB | Adobe PDF | View/Open |
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