Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/54108
Title: Dynamic funcitonal reorganizations and relationships with working memory performance in healthy aging
Author: Sala Llonch, Roser
Arenaza-Urquijo, E. M.
Valls-Pedret, Cinta
Vidal Piñeiro, Dídac
Bargalló Alabart, Núria​
Junqué i Plaja, Carme, 1955-
Bartrés Faz, David
Keywords: Memòria
Escorça cerebral
Envelliment
Memory
Cerebral cortex
Aging
Issue Date: 20-May-2012
Publisher: Frontiers Media
Abstract: In recent years, several theories have been proposed in attempts to identify the neural mechanisms underlying successful cognitive aging. Old subjects show increased neural activity during the performance of tasks, mainly in prefrontal areas, which is interpreted as a compensatory mechanism linked to functional brain efficiency. Moreover, resting-state studies have concluded that elders show disconnection or disruption of large-scale functional networks. We used functional MRI during resting-state and a verbal n-back task with different levels of memory load in a cohort of young and old healthy adults to identify patterns of networks associated with working memory and brain default mode. We found that the disruption of resting-state networks in the elderly coexists with task-related overactivations of certain brain areas and with reorganizations within these functional networks. Moreover, elders who were able to activate additional areas and to recruit a more bilateral frontal pattern within the task-related network achieved successful performance on the task. We concluded that the balanced and plastic reorganization of brain networks underlies successful cognitive aging. This observation allows the integration of several theories that have been proposed to date regarding the aging brain.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3389/fnhum.2012.00152
It is part of: Frontiers in Human Neuroscience, 2012, vol. 7, num. 6, p. 152
Related resource: http://dx.doi.org/10.3389/fnhum.2012.00152
URI: http://hdl.handle.net/2445/54108
ISSN: 1662-5161
Appears in Collections:Articles publicats en revistes (Psicologia Clínica i Psicobiologia)

Files in This Item:
File Description SizeFormat 
614077.pdf1.04 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons