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Title: Effectiveness of substituting cyclosporin A with tacrolimus in reducing gingival overgrowth in renal transplant patients
Author: Párraga Linares, Laura
Almendros-Marqués, Nieves
Berini Aytés, Leonardo
Gay Escoda, Cosme
Keywords: Immunosupressió
Trasplantament renal
Malalties periodontals
Efectes secundaris dels medicaments
Malalties de les genives
Kidney transplantation
Periodontal disease
Drug side effects
Gum diseases
Issue Date: 1-Sep-2009
Publisher: Medicina Oral SL
Abstract: Objectives: This study aims to evaluate the effectiveness of periodontal therapy combined with tacrolimus in the suppression of gingival overgrowth (GO) and the effect on GO of changing from cyclosporin A to tacrolimus. Patients and Methods: Sixteen renal transplant patients, averaging 52 years of age, whose kidney function was stable and were receiving treatment with cyclosporin A, were randomly assigned to one of two groups. In the experimental group, patients were instructed in oral hygiene and underwent periodontal treatment, whereas in the control group, only oral hygiene instructions were given. After the first visit and the change of medication from cyclosporine to tacrolimus in both groups, periodic clinical revisions were carried out for 3 months in order to assess the evolution of GO. Results: All patients showed a progressive decrease in GO. There were no statistically significant differences between the two groups (p>0.05). A greater decrease in GO occurred within the first month after changing the medication. Conclusions: No improved effectiveness in reducing GO was observed for periodontal therapy in combination with tacrolimus. Tacrolimus is an alternative to cyclosporine when attempting to avoid GO in patients with kidney transplants
Note: Reproducció del document publicat a:
It is part of: Medicina Oral, Patología Oral y Cirugia Bucal, 2009, vol. 14, num. 9, p. 429-433
ISSN: 1698-4447
Appears in Collections:Articles publicats en revistes (Odontostomatologia)

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