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http://hdl.handle.net/2445/54324
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DC Field | Value | Language |
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dc.contributor.author | Reverter Martín, Meritxell | - |
dc.contributor.author | Rentero Alfonso, Carles | - |
dc.contributor.author | García Melero, Ana | - |
dc.contributor.author | Hoque, Monira | - |
dc.contributor.author | Vilà de Muga, Sandra | - |
dc.contributor.author | Álvarez-Guaita, Anna | - |
dc.contributor.author | Conway, James | - |
dc.contributor.author | Wood, Peta | - |
dc.contributor.author | Cairns, Rose | - |
dc.contributor.author | Lykopoulou, Lila | - |
dc.contributor.author | Grinberg Vaisman, Daniel Raúl | - |
dc.contributor.author | Vilageliu i Arqués, Lluïsa | - |
dc.contributor.author | Bosch i Rodríguez, Marta | - |
dc.contributor.author | Heeren, Joerg | - |
dc.contributor.author | Blasi Cabús, Joan | - |
dc.contributor.author | Timpson, Paul | - |
dc.contributor.author | Pol i Sorolla, Albert | - |
dc.contributor.author | Tebar Ramon, Francesc | - |
dc.contributor.author | Murray, Rachael Z. | - |
dc.contributor.author | Grewal, Thomas | - |
dc.date.accessioned | 2014-05-21T14:18:55Z | - |
dc.date.available | 2014-05-21T14:18:55Z | - |
dc.date.issued | 2014-05-08 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/2445/54324 | - |
dc.description.abstract | Inhibition of cholesterol export from late endosomes causes cellular cholesterol imbalance, including cholesterol depletion in the trans-Golgi network (TGN). Here, using Chinese hamster ovary (CHO) Niemann-Pick type C1 (NPC1) mutant cell lines and human NPC1 mutant fibroblasts, we show that altered cholesterol levels at the TGN/endosome boundaries trigger Syntaxin 6 (Stx6) accumulation into VAMP3, transferrin, and Rab11-positive recycling endosomes (REs). This increases Stx6/VAMP3 interaction and interferes with the recycling of αVβ3 and α5β1 integrins and cell migration, possibly in a Stx6-dependent manner. In NPC1 mutant cells, restoration of cholesterol levels in the TGN, but not inhibition of VAMP3, restores the steady-state localization of Stx6 in the TGN. Furthermore, elevation of RE cholesterol is associated with increased amounts of Stx6 in RE. Hence, the fine-tuning of cholesterol levels at the TGN-RE boundaries together with a subset of cholesterol-sensitive SNARE proteins may play a regulatory role in cell migration and invasion. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1016/j.celrep.2014.03.043 | - |
dc.relation.ispartof | Cell Reports, 2014, vol. 7, num. 3, p. 883-897 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.celrep.2014.03.043 | - |
dc.rights | cc-by (c) Reverter Martín, Meritxell et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Colesterol | - |
dc.subject.classification | Transport biològic | - |
dc.subject.classification | Biologia molecular | - |
dc.subject.classification | Aparell de Golgi | - |
dc.subject.other | Cholesterol | - |
dc.subject.other | Biological transport | - |
dc.subject.other | Molecular biology | - |
dc.subject.other | Golgi apparatus | - |
dc.title | Cholesterol regulates Syntaxin 6 trafficking at the TGN-endosomal boundaries | eng |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 636070 | - |
dc.date.updated | 2014-05-21T14:18:55Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24746815 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Biomedicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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636070.pdf | 6.77 MB | Adobe PDF | View/Open |
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