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Title: Orthogonal protecting groups in the synthesis of tryptophanyl-hexahydropyrroloindoles
Author: Ruiz Sanchis, Pau
Savina, Svetlana A.
Acosta, Gerardo A.
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Keywords: Productes naturals marins
Química heterocíclica
Síntesi de pèptids
Marine natural products
Heterocyclic chemistry
Amino acids
Peptide synthesis
Issue Date: 22-Nov-2011
Publisher: Wiley-VCH
Abstract: The synthesis of various polycyclic systems containing a C3a-Ni bond between a hexahydropyrrolo[2,3-b]indole and an indole tryptophan is described here. A series of experiments were performed to determine the best combination of five orthogonal protecting groups and the best reaction conditions for formation of said bond, which is a common feature among many recently discovered marine natural products.
Note: Versió preprint del document publicat a:
It is part of: European Journal of Organic Chemistry, 2012, vol. 2012, num. 1, p. 67-73
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ISSN: 1434-193X
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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