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http://hdl.handle.net/2445/54946
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DC Field | Value | Language |
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dc.contributor.author | Kassan, Adam | - |
dc.contributor.author | Herms Fiol, Albert | - |
dc.contributor.author | Fernández-Vidal, Andrea | - |
dc.contributor.author | Bosch i Rodríguez, Marta | - |
dc.contributor.author | Schieber, Nicole L. | - |
dc.contributor.author | Reddy, Babu J. N. | - |
dc.contributor.author | Fajardo, Alba | - |
dc.contributor.author | Gelabert Baldrich, Mariona | - |
dc.contributor.author | Tebar Ramon, Francesc | - |
dc.contributor.author | Enrich Bastús, Carles | - |
dc.contributor.author | Gross, Steven P. | - |
dc.contributor.author | Parton, Robert G. | - |
dc.contributor.author | Pol i Sorolla, Albert | - |
dc.date.accessioned | 2014-06-12T09:01:49Z | - |
dc.date.available | 2014-06-23T22:02:05Z | - |
dc.date.issued | 2013-12-23 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.uri | http://hdl.handle.net/2445/54946 | - |
dc.description.abstract | Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic reticulum (ER) to LDs in response to fatty acids to characterize the initial steps of LD formation occurring in lipid-starved cells. Initially, arriving lipids are rapidly packed in LDs that are resistant to starvation (pre-LDs). Pre-LDs are restricted ER microdomains with a stable core of neutral lipids. Subsequently, a first round of"emerging" LDs is nucleated, providing additional lipid storage capacity. Finally, in proportion to lipid concentration, new rounds of LDs progressively assemble. Confocal microscopy and electron tomography suggest that emerging LDs are nucleated in a limited number of ER microdomains after a synchronized stepwise process of protein gathering, lipid packaging, and recognition by Plin3 and Plin2. A comparative analysis demonstrates that the acyl-CoA synthetase 3 is recruited early to the assembly sites, where it is required for efficient LD nucleation and lipid storage. | - |
dc.format.extent | 23 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Rockefeller University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1083/jcb.201305142 | - |
dc.relation.ispartof | Journal of Cell Biology, 2013, vol. 203, num. 6, p. 985-1001 | - |
dc.relation.uri | http://dx.doi.org/10.1083/jcb.201305142 | - |
dc.rights | cc-by (c) Kassan, A. et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Coenzims | - |
dc.subject.classification | Metabolisme dels lípids | - |
dc.subject.classification | Transport biològic | - |
dc.subject.other | Coenzymes | - |
dc.subject.other | Lipid metabolism | - |
dc.subject.other | Biological transport | - |
dc.title | Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains. | eng |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 636833 | - |
dc.date.updated | 2014-06-11T07:15:19Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24368806 | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
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636833.pdf | 8.59 MB | Adobe PDF | View/Open |
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