Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/54981
Title: Recent advances in lamellarin alkaloids: isolation, synthesis and activity
Author: Pla Queral, Daniel
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Keywords: Alcaloides
Productes naturals marins
Compostos heterocíclics
Medicaments antineoplàstics
Alkaloids
Marine natural products
Heterocyclic compounds
Antineoplastic agents
Issue Date: Oct-2008
Publisher: Bentham Science Publishers
Abstract: Lamellarins are a large family of marine alkaloids with potential anticancer activity that have been isolated from diverse marine organisms, mainly ascidians and sponges. All lamellarins feature a 3,4-diarylpyrrole system. Pentacyclic lamellarins, whose polyheterocyclic system has a pyrrole core, are the most active compounds. Some of these alkaloids are potently cytotoxic to various tumor cell lines. To date, Lam-D and Lam-H have been identified as lead compounds for the inhibition of topoisomerase I and HIV-1 integrase, respectively nuclear enzymes which are over-expressed in deregulation disorders. Moreover,these compounds have been reported for their efficacy in treatment of multi-drug resistant (MDR) tumors cells without mediated drug efflux, as well as their immunomodulatory activity and selectivity towards melanoma cell lines. This article is an overview of recent literature on lamellarins, encompassing their isolation, recent synthetic strategies for their total synthesis, the preparation of their analogs, studies on their mechanisms of action, and their structure-activity relationships (SAR).
Note: Versió postprint del document publicat a: http://dx.doi.org/10.2174/187152008785914789
It is part of: Anti-Cancer Agents In Medicinal Chemistry, 2008, vol. 8, num. 7, p. 746-760
Related resource: http://dx.doi.org/10.2174/187152008785914789
URI: http://hdl.handle.net/2445/54981
ISSN: 1871-5206
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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